Medical Action Ontology

Last uploaded: July 29, 2024
Preferred Name

pro-B cell
Synonyms

pre-B cell (Philadelphia nomenclature)

pre-pro B cell

progenitor B-cell

pro-B-lymphocyte

progenitor B cell

progenitor B lymphocyte

pro-B lymphocyte

progenitor B-lymphocyte

pro-B-cell

Definitions

A progenitor cell of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but not yet fully committed to the B cell lineage until the expression of PAX5 occurs. Human pro-B cells are reportedly CD10-positive, CD22-positive, CD34-positive, CD38-positive, CD45-low, CD48-positive, CD79a-positive, CD127-positive, CD184-positive, RAG-positive, TdT-positive, Vpre-B-positive, pre-BCR-negative, IgD-negative, and IgM-negative. Transcription factors expressed: Pax5-positive, EBF-positive, E2A-negative, Ikaros-negative, and PU.1-negative.

ID

http://purl.obolibrary.org/obo/CL_0000826

comment

Human pro-B cells are reportedly CD10-positive, CD22-positive, CD34-positive, CD38-positive, CD45-low, CD48-positive, CD79a-positive, CD127-positive, CD184-positive, RAG-positive, TdT-positive, Vpre-B-positive, pre-BCR-negative, IgD-negative, and IgM-negative. Transcription factors expressed: Pax5-positive, EBF-positive, E2A-negative, Ikaros-negative, and PU.1-negative.

database_cross_reference

BTO:0003104

definition

A progenitor cell of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but not yet fully committed to the B cell lineage until the expression of PAX5 occurs.

develops_from

http://purl.obolibrary.org/obo/CL_0000051

has part

http://purl.obolibrary.org/obo/PR_000001903

http://purl.obolibrary.org/obo/PR_000006611

has_broad_synonym

pre-pro B cell

has_exact_synonym

progenitor B-cell

pro-B-lymphocyte

progenitor B cell

progenitor B lymphocyte

pro-B lymphocyte

progenitor B-lymphocyte

pro-B-cell

has_related_synonym

pre-B cell (Philadelphia nomenclature)

label

pro-B cell

overlaps

http://purl.obolibrary.org/obo/PR_000001903

http://purl.obolibrary.org/obo/PR_000006611

participates in

http://purl.obolibrary.org/obo/GO_0033152

prefixIRI

CL:0000826

prefLabel

pro-B cell

treeView

http://purl.obolibrary.org/obo/CL_0000051

subClassOf

http://purl.obolibrary.org/obo/CL_0000838

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Mapping To Ontology Source
http://purl.obolibrary.org/obo/CL_0000826 CL SAME_URI
http://purl.obolibrary.org/obo/CL_0000826 UBERON SAME_URI
http://purl.obolibrary.org/obo/CL_0000826 CLO SAME_URI
http://purl.obolibrary.org/obo/CL_0000826 CCONT SAME_URI
http://purl.obolibrary.org/obo/CL_0000826 CHEAR SAME_URI
http://purl.obolibrary.org/obo/CL_0000826 HRA SAME_URI
http://purl.obolibrary.org/obo/CL_0000826 OBI_BCGO SAME_URI
http://purl.obolibrary.org/obo/CL_0000826 PCL SAME_URI
http://purl.obolibrary.org/obo/CL_0000826 GO-PLUS SAME_URI
http://purl.obolibrary.org/obo/CL_0000826 BERO SAME_URI
http://purl.obolibrary.org/obo/CL_0000826 HHEAR SAME_URI
http://purl.obolibrary.org/obo/CL_0000826 UPHENO SAME_URI
http://purl.obolibrary.org/obo/CL_0000826 NIFSTD SAME_URI
http://purl.obolibrary.org/obo/CL_0000826 KTAO SAME_URI
http://purl.obolibrary.org/obo/CL_0000826 EFO SAME_URI
http://purl.obolibrary.org/obo/CL_0000826 OBA SAME_URI
http://purl.obolibrary.org/obo/ZFA_0009349 ZFA LOOM
http://purl.obolibrary.org/obo/ZFA_0009349 ZP LOOM
http://purl.org/obo/owl/CL#CL_0000826 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CL_0000826 CL LOOM
http://purl.obolibrary.org/obo/CL_0000826 UBERON LOOM
http://purl.obolibrary.org/obo/CL_0000826 CLO LOOM
http://purl.obolibrary.org/obo/CL_0000826 CCONT LOOM
http://purl.obolibrary.org/obo/CL_0000826 CHEAR LOOM
http://purl.obolibrary.org/obo/CL_0000826 OBI_BCGO LOOM
http://purl.obolibrary.org/obo/CL_0000826 PCL LOOM
http://purl.obolibrary.org/obo/CL_0000826 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CL_0000826 HHEAR LOOM
http://purl.obolibrary.org/obo/CL_0000826 UPHENO LOOM
http://purl.obolibrary.org/obo/CL_0000826 NIFSTD LOOM
http://purl.obolibrary.org/obo/CL_0000826 KTAO LOOM
http://purl.obolibrary.org/obo/CL_0000826 EFO LOOM
http://purl.obolibrary.org/obo/CL_0000826 OBA LOOM
http://purl.obolibrary.org/obo/TAO_0009349 TAO LOOM