loading...| Preferred Name | innate lymphoid cell | |
| Synonyms |
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| ID |
http://purl.obolibrary.org/obo/LMMA_00620 |
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| definition |
A cell of the lymphoid lineage that lacks expression of rearranged antigen-specific receptors, existing mainly in non-lymphoid tissues as tissue-resident cells. These cells have physiological functions analogous to helper T cells, while also including the cytotoxic NK cells. They can be divided into 3 groups based on the cytokines they produce: Group 1 (ILC and NK cells) produces type 1 cytokines (IFNgamma and TNF); Group 2 (nuocytes) produces type 2 cytokines (IL-4, -5, -9, and -13); and Group 3 (ILC3 and lymphoid tissue-inducer cells) produces IL-17A and/or IL-22. They play an important role in protective immunity and in the regulation of homeostasis and inflammation. Dysregulation can result in allergic responses (asthma) and autoimmune disease. |
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| Developmental_Stage | ||
| evidence |
published |
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| has_domain | ||
| hasDbXref |
LMHA:00623 CL:0001065 |
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| in_organism | ||
| in_stage | ||
| in_stage_range | ||
| label |
innate lymphoid cell |
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| prefixIRI |
LMMA:00620 |
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| prefLabel |
innate lymphoid cell |
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| Theiler_Stage | ||
| subClassOf |