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Logical Observation Identifier Names and Codes
Last uploaded:
January 16, 2025
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Id | http://purl.bioontology.org/ontology/LNC/83057-0
http://purl.bioontology.org/ontology/LNC/83057-0
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Preferred Name | Programmed cell death ligand 1 by clone SP142:PrThr:Pt:Tiss:Ord:Immune stain |
Synonyms |
PD-L1 by SP142 Tiss Ql ImStn
Programmed cell death ligand 1 by clone SP142:Presence or Threshold:To identify measures at a point in time:Tissue, unspecified:Ordinal:Immune stain
PD-L1 by clone SP142 Immune stain Ql (Tiss)
PD-L1 by clone SP142 [Presence] in Tissue by Immune stain
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Type | http://www.w3.org/2002/07/owl#Class |
All Properties
altLabel | PD-L1 by SP142 Tiss Ql ImStn
Programmed cell death ligand 1 by clone SP142:Presence or Threshold:To identify measures at a point in time:Tissue, unspecified:Ordinal:Immune stain
PD-L1 by clone SP142 Immune stain Ql (Tiss)
PD-L1 by clone SP142 [Presence] in Tissue by Immune stain
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prefLabel | Programmed cell death ligand 1 by clone SP142:PrThr:Pt:Tiss:Ord:Immune stain
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LOINC time aspect | Pt
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VERSION LAST CHANGED | 2.73
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notation | 83057-0
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Answer list OID | 1.3.6.1.4.1.12009.10.1.2764
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Has class | |
Has property | |
Answer list ID | LL4167-4
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Scope Statement | This term should be used to report the degree of PD-L1 (CD274) protein expression in tumor cells as determined by immune staining with anti-PD-L1 clone SP142. Patients with certain cancers, such as non small cell lung cancer (NSCLC) or urothelial carcinoma, whose tumors are positive for PD-L1 by SP142, may be eligible for anti-programmed death 1 (PD-1) receptor antibody therapy, which effectively prevents the binding of PD-L1 to PD-1. The percentage of viable tumor cells that show partial or complete PD-L1 membrane staining is reported using [LOINC: 83053-9]. If at least 50% of tumor cells or at least 10% of inflammatory cells stain positive with SP142, the tumor is considered to have high PD-L1 expression, and if 1 to 50% of tumor cells and 1 to 10% of inflammatory cells stain positive, the tumor has low expression. If <1% of both tumor and inflammatory cells stain positive, the tumor is considered to have no PD-L1 expression. This term was created for, but is not limited in use to, the Ventana PD-L1 (SP142) assay, which, as of November 2016, is FDA-approved as a companion diagnostic to assess whether patients with certain cancers are eligible for atezolizumab therapy.
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LOR | Both
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COMMON ORDER RANK | 0
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LOINC property | PrThr
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LOINC system | Tiss
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LCL | PATH
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VERSION FIRST RELEASED | 2.58
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CONSUMER NAME | PD-L1 by Clone SP142, Tissue
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Has scale | |
Has component | |
Has method | |
Has system | |
LCS | ACTIVE
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Related names 2 | B7 homolog 1; B7-H1; CD274; Cluster of differentiation 274; i; IHC; Imm; Immunohistochemical stain; Immunostain; ImStn; Imun; Imune; Ordinal; PATHOLOGY; PDL1; PD-L1; PD-L1 by SP142; Point in time; PR; QL; Qual; Qualitative; Random; Screen; St; Stains; Stn; Tissue; Tissue
unspecified
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LCT | MIN
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Has answer | |
LOINC scale type | Ord
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subClassOf | |
Semantic type UMLS property | |
measures | |
LOINC component | Programmed cell death ligand 1 by clone SP142
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LOINC method type | Immune stain
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type | |
COMMON TEST RANK | 17666
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LCN | 1
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Has time aspect | |
tui | T201
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cui | C4298261
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Answer list name | High expression|Low expression|No express
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analyzes |
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