Kidney Tissue Atlas Ontology

Last uploaded: March 16, 2024
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Preferred Name

Impaired renal concentrating ability
Synonyms

Urine concentrating defect

Urine concentration defect
Definitions

A defect in the ability to concentrate the urine. An impairment in renal concentrating ability can be easily recognized by the maximum concentrating ability (Umax) as determined by the urine osmolality reached after a fixed period of dehydration. Inability to maximally concentrate the urine is related to one or both of two basic tubular defects: 1) a failure of maximal free-water generation by the diluting segment in the ascending limb of Henle's loop; and 2) a failure of the distal tubular epithelium to achieve maximum permeability to water during water deprivation.
ID

http://purl.obolibrary.org/obo/HP_0004727
comment

An impairment in renal concentrating ability can be easily recognized by the maximum concentrating ability (Umax) as determined by the urine osmolality reached after a fixed period of dehydration. Inability to maximally concentrate the urine is related to one or both of two basic tubular defects: 1) a failure of maximal free-water generation by the diluting segment in the ascending limb of Henle's loop; and 2) a failure of the distal tubular epithelium to achieve maximum permeability to water during water deprivation.
database_cross_reference

UMLS:C1859819
has exact synonym

Urine concentrating defect

Urine concentration defect
has_alternative_id

HP:0005568
id

HP:0004727
imported from

http://purl.obolibrary.org/obo/hp.owl
label

Impaired renal concentrating ability
notation

HP:0004727
prefLabel

Impaired renal concentrating ability
textual definition

A defect in the ability to concentrate the urine.
subClassOf

http://purl.obolibrary.org/obo/HP_0011038
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