loading...| Preferred Name |
tumor necrosis factor-alpha |
|
| Synonyms |
TNFA TNFSF2 tumor necrosis factor ligand superfamily member 2 TNF TNF-alpha cachexin cachectin |
|
| Definitions |
factor alpha (TNF) is a pleiotropic cytokine that mediates apoptosis, cell proliferation, immunomodulation, inflammation, viral replication, allergy, arthritis, septic shock, insulin resistance, autoimmune diseases, and other pathological conditions. TNF transduces these cellular responses through two distinct receptors: type I, which are expressed on all cell types, and type II, which are expressed only on cells of the immune system and endothelial cells. |
|
| ID |
http://purl.obolibrary.org/obo/PR_000000134 |
|
| alt_id |
IDOMAL_0000783 |
|
| definition |
factor alpha (TNF) is a pleiotropic cytokine that mediates apoptosis, cell proliferation, immunomodulation, inflammation, viral replication, allergy, arthritis, septic shock, insulin resistance, autoimmune diseases, and other pathological conditions. TNF transduces these cellular responses through two distinct receptors: type I, which are expressed on all cell types, and type II, which are expressed only on cells of the immune system and endothelial cells. |
|
| definition_source |
ISBN:0-8493-15-67-0 |
|
| has_exact_synonym |
tumor necrosis factor ligand superfamily member 2 TNF TNF-alpha cachexin cachectin |
|
| has_related_synonym |
TNFA TNFSF2 |
|
| has_synonym |
TNFA TNFSF2 tumor necrosis factor ligand superfamily member 2 TNF TNF-alpha cachexin cachectin |
|
| label |
tumor necrosis factor-alpha |
|
| prefixIRI |
PR:000000134 |
|
| prefLabel |
tumor necrosis factor-alpha |
|
| subClassOf |