bisphosphonate

disphosphonate

disphosphonates

bisphosphonates

Bisphosphonates (also called diphosphonates) are a class of drugs that prevent the loss of bone mass, used to treat osteoporosis and similar diseases. They are called bisphosphonates because they have two phosphonate (PO3) groups and are similar in structure to pyrophosphate. Evidence shows that they reduce the risk of osteoporotic fracture in those who have had previous fractures however do not reduce fracture risk in those with osteoporosis who have not previously had a fracture.[1][2] Bone undergoes constant turnover and is kept in balance (homeostasis) by osteoblasts creating bone and osteoclasts destroying bone. Bisphosphonates inhibit the digestion of bone by encouraging osteoclasts to undergo apoptosis, or cell death, thereby slowing bone loss.[3] The uses of bisphosphonates include the prevention and treatment of osteoporosis, osteitis deformans ("Paget's disease of bone"), bone metastasis (with or without hypercalcaemia), multiple myeloma, primary hyperparathyroidism, osteogenesis imperfecta, and other conditions that feature bone fragility. source: http://en.wikipedia.org/wiki/Bisphosphonate

http://scai.fraunhofer.de/HuPSON#SCAIVPH_00001421

Bisphosphonates (also called diphosphonates) are a class of drugs that prevent the loss of bone mass, used to treat osteoporosis and similar diseases. They are called bisphosphonates because they have two phosphonate (PO3) groups and are similar in structure to pyrophosphate. Evidence shows that they reduce the risk of osteoporotic fracture in those who have had previous fractures however do not reduce fracture risk in those with osteoporosis who have not previously had a fracture.[1][2] Bone undergoes constant turnover and is kept in balance (homeostasis) by osteoblasts creating bone and osteoclasts destroying bone. Bisphosphonates inhibit the digestion of bone by encouraging osteoclasts to undergo apoptosis, or cell death, thereby slowing bone loss.[3] The uses of bisphosphonates include the prevention and treatment of osteoporosis, osteitis deformans ("Paget's disease of bone"), bone metastasis (with or without hypercalcaemia), multiple myeloma, primary hyperparathyroidism, osteogenesis imperfecta, and other conditions that feature bone fragility. source: http://en.wikipedia.org/wiki/Bisphosphonate

disphosphonate

disphosphonates

bisphosphonates

bisphosphonate

22103779

hupson:SCAIVPH_00001421

bisphosphonate

http://www.co-ode.org/ontologies/galen#Drug