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Health and Social Person-centric Ontology
Last uploaded:
June 9, 2023
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| Preferred Name | 3,3',5-triiodo-L-thyronine | |
| Synonyms |
L-3,5,3'-Triiodothyronine T3 liothyroninum Liothyronine L-T3 liothyronine 3,5,3'-Triiodo-L-thyronine 3,5,3'-Triiodothyronine 4-(4-hydroxy-3-iodophenoxy)-3,5-diiodo-L-phenylalanine Triiodothyronine O-(4-hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine 3,5,3'TRIIODOTHYRONINE liotironina Tresitope Tertroxin 3,3',5-triiodo-L-thyronine |
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| Definitions |
An iodothyronine compound having iodo substituents at the 3-, 3'- and 5-positions. Although some is produced in the thyroid, most of the 3,3',5-triiodo-L-thyronine in the body is generated by mono-deiodination of L-thyroxine in the peripheral tissues. Its metabolic activity is about 3 to 5 times that of L-thyroxine. The sodium salt is used in the treatment of hypothyroidism. |
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| ID |
http://purl.obolibrary.org/obo/CHEBI_18258 |
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| bearer_of | ||
| charge |
0
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| database_cross_reference |
SNOMEDCT:61275002 CiteXplore:15206581 MeSH:D014284 KEGG COMPOUND:C02465 Beilstein:2710227 SNOMEDCT:350358003 KEGG COMPOUND:6893-02-3 ChemIDplus:6893-02-3 NCIt:C2303 NCIt:C907 MetaCyc:CPD-10813 KEGG:C02465 DrugBank:DB00279 PMID:19339791 PMID:11738632 Reaxys:2710227 HMDB:HMDB0000265 CAS:6893-02-3 LINCS:LSM-3991 Drug_Central:1585 PDBeChem:T3 KEGG:D08128 PMID:15206581 Wikipedia:Triiodothyronine
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|
| definition |
An iodothyronine compound having iodo substituents at the 3-, 3'- and 5-positions. Although some is produced in the thyroid, most of the 3,3',5-triiodo-L-thyronine in the body is generated by mono-deiodination of L-thyroxine in the peripheral tissues. Its metabolic activity is about 3 to 5 times that of L-thyroxine. The sodium salt is used in the treatment of hypothyroidism.
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| formula |
C15H12I3NO4
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| has_alternative_id |
CHEBI:11702 CHEBI:9722 CHEBI:45840 CHEBI:11701 CHEBI:13059 CHEBI:19894
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| has_exact_synonym |
3,3',5-triiodo-L-thyronine
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| has_obo_namespace |
chebi_ontology
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| has_related_synonym |
L-3,5,3'-Triiodothyronine T3 liothyroninum Liothyronine L-T3 liothyronine 3,5,3'-Triiodo-L-thyronine 3,5,3'-Triiodothyronine 4-(4-hydroxy-3-iodophenoxy)-3,5-diiodo-L-phenylalanine Triiodothyronine O-(4-hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine 3,5,3'TRIIODOTHYRONINE liotironina Tresitope Tertroxin
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| has_role | ||
| id |
CHEBI:18258
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| in_subset | ||
| inchi |
InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1
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| inchikey |
AUYYCJSJGJYCDS-LBPRGKRZSA-N
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| label |
3,3',5-triiodo-L-thyronine
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|
| mass |
650.97350
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| monoisotopicmass |
650.79004
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| notation |
CHEBI:18258
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| preferred label |
3,3',5-triiodo-L-thyronine
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| prefLabel |
3,3',5-triiodo-L-thyronine
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| smiles |
N[C@@H](Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1)C(O)=O
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| subClassOf |
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