loading...| Preferred Name | circumventricular organ | |
| Synonyms |
CVO circumventricular organ of neuraxis circumventricular organ |
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| Definitions |
Any of any of the secretory or sensory organs located in the brain region around or in relation to the ventricular system that are characterized by extensive vasculature and a lack of a normal blood brain barrier (BBB) and allow for the linkage between the central nervous system and peripheral blood flow. |
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| ID |
http://purl.obolibrary.org/obo/UBERON_0005408 |
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| altLabel |
CVO circumventricular organ of neuraxis circumventricular organ |
|
| definition |
Any of any of the secretory or sensory organs located in the brain region around or in relation to the ventricular system that are characterized by extensive vasculature and a lack of a normal blood brain barrier (BBB) and allow for the linkage between the central nervous system and peripheral blood flow. |
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| depiction |
http://upload.wikimedia.org/wikipedia/commons/7/7d/Gray734.png |
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| has exact synonym |
CVO circumventricular organ of neuraxis circumventricular organ |
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| has_obo_namespace |
uberon |
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| id |
UBERON:0005408 |
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| in_subset | ||
| label |
circumventricular organ |
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| notation |
UBERON:0005408 |
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| prefLabel |
circumventricular organ |
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| structure_notes |
CVOs contain neural tissue and are an integral part of neuroendocrine function; all of the CVOs, besides the subcommissural organ, contain extensive vasculature and fenestrated capillaries which leads to a leaky BBB at the site of the organs; the lack of a BBB allows CVOs to act as an alternative route for peptides and hormones in the neural tissue to the peripheral blood stream, while still protecting it from toxic substances |
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| taxon_notes |
All vertebrates possess at least 4 circumventricular organs (including the hypothalamus) which can monitor the contents of the cerebrospinal fluid and secrete additional substances into it. (Butler, 1996, p. 330) |
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| xRef |
MESH:D066280 neuronames:1242 EMAPA:35243 Wikipedia:Circumventricular_organs MA:0002942 NLXANAT:20090312 FMA:84081 BTO:0006267 |
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| subClassOf |