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Human Phenotype Ontology
Last uploaded:
January 16, 2025
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| Id | http://purl.obolibrary.org/obo/HP_0008682
http://purl.obolibrary.org/obo/HP_0008682
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|---|---|
| Preferred Name | Renal tubular epithelial necrosis |
| Definitions |
Coagulative necrosis of tubular epithelial cells, defined as cells with increased cytoplasmic eosinophilia and nucleus that has a condensed chromatin pattern with fuzzy nuclear contour or has barely visible nuclear basophilic staining. The extent of cortical tubular necrosis is scoredsemiquantitatively as none, mild (less than 25% tubules with necrosis), moderate (25-50 percent), and severe (over 50%).
Renal tubular epithelial necrosis is a histomorphological definition that corresponds to the clinical term of acture tubular necrosis. Acute death of renal tubular cells that usually results from prolonged renal ischemia, nephrotoxins, or sepsis. The clinical course of acute tubular necrosis may be divided into initiation, maintenance, and recovery phases.
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| Synonyms |
Renal tubular necrosis
Acute tubular necrosis
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | Coagulative necrosis of tubular epithelial cells, defined as cells with increased cytoplasmic eosinophilia and nucleus that has a condensed chromatin pattern with fuzzy nuclear contour or has barely visible nuclear basophilic staining. The extent of cortical tubular necrosis is scoredsemiquantitatively as none, mild (less than 25% tubules with necrosis), moderate (25-50 percent), and severe (over 50%). |
|---|---|
| label |
Renal tubular epithelial necrosis
|
| comment |
Renal tubular epithelial necrosis is a histomorphological definition that corresponds to the clinical term of acture tubular necrosis. Acute death of renal tubular cells that usually results from prolonged renal ischemia, nephrotoxins, or sepsis. The clinical course of acute tubular necrosis may be divided into initiation, maintenance, and recovery phases.
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| prefLabel |
Renal tubular epithelial necrosis
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| database_cross_reference |
SNOMEDCT_US:35455006
UMLS:C0022672
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| notation |
HP:0008682
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| id |
HP:0008682
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| has_obo_namespace |
human_phenotype
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| subClassOf | |
| type | |
| has_exact_synonym |
Renal tubular necrosis
Acute tubular necrosis
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