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Human Phenotype Ontology
Last uploaded:
January 16, 2025
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| Id | http://purl.obolibrary.org/obo/HP_0000824
http://purl.obolibrary.org/obo/HP_0000824
|
|---|---|
| Preferred Name | Decreased response to growth hormone stimulation test |
| Definitions |
Insufficient responses to growth hormone (GH) provocation tests. GH deficiency is defined as a serum peak GH concentration less than 10 ng/mL on provocation with a combination of at least two separate stimulation tests.
GH stimulation tests are performed with various stimuli, such as insulin, L-dopa, arginine, and growth hormone releasing hormone (GHRH). The test using insulin as a stimulus is classically recommended, but this test has potential risks such as hypoglycemia. The effects of growth hormone are mediated almost exclusively by insulin-like growth factor 1(IGF-1), which is produced primarily in the liver. Growth hormone deficiency refers to inadequate levels of GH (and therefore IGF-1), resulting in growth retardation in children and metabolic disturbances in adults.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | Insufficient responses to growth hormone (GH) provocation tests. GH deficiency is defined as a serum peak GH concentration less than 10 ng/mL on provocation with a combination of at least two separate stimulation tests. |
|---|---|
| label |
Decreased response to growth hormone stimulation test
|
| comment |
GH stimulation tests are performed with various stimuli, such as insulin, L-dopa, arginine, and growth hormone releasing hormone (GHRH). The test using insulin as a stimulus is classically recommended, but this test has potential risks such as hypoglycemia. The effects of growth hormone are mediated almost exclusively by insulin-like growth factor 1(IGF-1), which is produced primarily in the liver. Growth hormone deficiency refers to inadequate levels of GH (and therefore IGF-1), resulting in growth retardation in children and metabolic disturbances in adults.
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| prefLabel |
Decreased response to growth hormone stimulation test
|
| database_cross_reference |
UMLS:C3714796
SNOMEDCT_US:2109003
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| notation |
HP:0000824
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| id |
HP:0000824
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| has_obo_namespace |
human_phenotype
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| subClassOf | |
| has_alternative_id |
HP:0008195
HP:0008206
HP:0000861
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| type | |
| treeView |
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