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Homeostasis imbalance process ontology
Last uploaded:
April 3, 2024
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| Preferred Name | AKT kinase | |
| Synonyms |
PKB AKT serine-threonine kinase Akt |
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| Definitions |
A protein that has a core domain composition consisting of a PH domain (Pfam:PF00169), Protein kinase domain (Pfam:PF00069) and a Protein kinase C terminal domain (Pfam:PF00433). Mammals have three genes encoding AKT1, AKT2 and AKT3. The second messenger phosphatidylinositol-3,4,5-trisphosphate [PIP(3)], product of phosphatidylinositol 3-kinase, acts largely through its role as a kinase activator. Binding of the pleckstrin domain to PIP(3) results in its targeting to the plasma membrane. Full activity is gained only after phosphorylation at two sites. |
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| ID |
http://purl.obolibrary.org/obo/PR_000029189 |
|
| definition |
A protein that has a core domain composition consisting of a PH domain (Pfam:PF00169), Protein kinase domain (Pfam:PF00069) and a Protein kinase C terminal domain (Pfam:PF00433). Mammals have three genes encoding AKT1, AKT2 and AKT3. The second messenger phosphatidylinositol-3,4,5-trisphosphate [PIP(3)], product of phosphatidylinositol 3-kinase, acts largely through its role as a kinase activator. Binding of the pleckstrin domain to PIP(3) results in its targeting to the plasma membrane. Full activity is gained only after phosphorylation at two sites. A protein that has a core domain composition consisting of a PH domain (Pfam:PF00169), Protein kinase domain (Pfam:PF00069) and a Protein kinase C terminal domain (Pfam:PF00433). Mammals have three genes encoding AKT1, AKT2 and AKT3. The second messenger phosphatidylinositol-3,4,5-trisphosphate [PIP(3)], product of phosphatidylinositol 3-kinase, acts largely through its role as a kinase activator. Binding of the pleckstrin domain to PIP(3) results in its targeting to the plasma membrane. Full activity is gained only after phosphorylation at two sites.
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| has role | ||
| has_broad_synonym |
PKB
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| has_exact_synonym |
AKT serine-threonine kinase Akt
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| label |
AKT kinase
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| prefixIRI |
PR:000029189
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| prefLabel |
AKT kinase
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| subClassOf |
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| Mapping To | Ontology | Source |
|---|---|---|
| http://purl.obolibrary.org/obo/PR_000029189 | PR | SAME_URI |
| http://purl.obolibrary.org/obo/PR_000029189 | GO-PLUS | SAME_URI |
| http://purl.obolibrary.org/obo/PR_000029189 | CIDO | SAME_URI |
| http://purl.obolibrary.org/obo/PR_000029189 | OBA | SAME_URI |
| http://purl.obolibrary.org/obo/PR_000029189 | PR | LOOM |
| http://purl.obolibrary.org/obo/PR_000029189 | GO-PLUS | LOOM |
| http://purl.obolibrary.org/obo/PR_000029189 | CIDO | LOOM |
| http://purl.obolibrary.org/obo/PR_000029189 | OBA | LOOM |