Preferred Name |
Fluvastatin |
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Synonyms |
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Definitions |
A synthetic lipid-lowering agent with antilipidemic and potential antineoplastic properties. Fluvastatin competitively inhibits hepatic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, which catalyzes the conversion of HMG-CoA to mevalonate, a key step in cholesterol synthesis. This agent lowers plasma cholesterol and lipoprotein levels, and modulates immune responses through the suppression of MHC II (major histocompatibility complex II) on interferon gamma-stimulated antigen-presenting cells such as human vascular endothelial cells. Due to its anti-inflammatory effects mediated by alterations of lipid metabolism, fluvastatin may possess chemopreventive and therapeutic antineoplastic properties. Been shown to protects cochleae from damage by high-level noise. |
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ID |
http://purl.obolibrary.org/obo/HIO_0000304 |
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comment |
Been shown to protects cochleae from damage by high-level noise. |
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description |
A synthetic lipid-lowering agent with antilipidemic and potential antineoplastic properties. Fluvastatin competitively inhibits hepatic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, which catalyzes the conversion of HMG-CoA to mevalonate, a key step in cholesterol synthesis. This agent lowers plasma cholesterol and lipoprotein levels, and modulates immune responses through the suppression of MHC II (major histocompatibility complex II) on interferon gamma-stimulated antigen-presenting cells such as human vascular endothelial cells. Due to its anti-inflammatory effects mediated by alterations of lipid metabolism, fluvastatin may possess chemopreventive and therapeutic antineoplastic properties. |
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created_by |
Jade Hotchkiss |
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creation_date |
2019-08-06T08:52:56.635927Z |
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database cross reference |
NCIT:C61768 |
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definition source | ||
existence in other ontologies |
Sufficient |
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label |
Fluvastatin |
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prefixIRI |
HIO:0000304 |
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prefLabel |
Fluvastatin |
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source |
https://www.ncbi.nlm.nih.gov/pubmed/http://purl.obolibrary.org/obo/HIO_29445111 |
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subClassOf |