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Hearing Impairment Ontology
Last uploaded:
October 31, 2019
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| Id | http://purl.obolibrary.org/obo/HIO_0000304
http://purl.obolibrary.org/obo/HIO_0000304
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|---|---|
| Preferred Name | Fluvastatin |
| Definitions |
Been shown to protects cochleae from damage by high-level noise.
A synthetic lipid-lowering agent with antilipidemic and potential antineoplastic properties. Fluvastatin competitively inhibits hepatic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, which catalyzes the conversion of HMG-CoA to mevalonate, a key step in cholesterol synthesis. This agent lowers plasma cholesterol and lipoprotein levels, and modulates immune responses through the suppression of MHC II (major histocompatibility complex II) on interferon gamma-stimulated antigen-presenting cells such as human vascular endothelial cells. Due to its anti-inflammatory effects mediated by alterations of lipid metabolism, fluvastatin may possess chemopreventive and therapeutic antineoplastic properties.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| prefLabel |
Fluvastatin
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|---|---|
| label |
Fluvastatin
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| comment |
Been shown to protects cochleae from damage by high-level noise.
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| description |
A synthetic lipid-lowering agent with antilipidemic and potential antineoplastic properties. Fluvastatin competitively inhibits hepatic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, which catalyzes the conversion of HMG-CoA to mevalonate, a key step in cholesterol synthesis. This agent lowers plasma cholesterol and lipoprotein levels, and modulates immune responses through the suppression of MHC II (major histocompatibility complex II) on interferon gamma-stimulated antigen-presenting cells such as human vascular endothelial cells. Due to its anti-inflammatory effects mediated by alterations of lipid metabolism, fluvastatin may possess chemopreventive and therapeutic antineoplastic properties.
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| creation_date |
2019-08-06T08:52:56.635927Z
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| created_by |
Jade Hotchkiss
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| existence in other ontologies |
Sufficient
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| prefixIRI |
HIO:0000304
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| database cross reference |
NCIT:C61768
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| subClassOf | |
| definition source | |
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