loading...| Preferred Name |
Binding of BoNT toxins to gut epithelial membrane |
|
| Synonyms |
|
|
| Definitions |
Authored: Krupa, S, Gopinathrao, G, 2006-06-15 10:36:11 Botulinum neurotoxins (BoNTs) bind to polysialogangliosides, including GT1b, GD1b and GQ1b and synaptotagmin polypeptides on the neuronal plasma membrane (Verderio et al., 2006). In the body, this dual binding may have the effect of targeting BoNTs to specific regions of the neuromuscular junction for endocytosis. Different serotypes are known to bind to different receptors: Bont/A to SV2, Bont/B and G to Syt1 and Syt2 with different affinities. Edited: Gopinathrao, G, 2006-06-15 22:12:29 Reviewed: Ichtchenko, K, 2007-08-03 18:17:25 |
|
| ID |
http://purl.obolibrary.org/obo/HINO_0026836 |
|
| comment |
Authored: Krupa, S, Gopinathrao, G, 2006-06-15 10:36:11 Botulinum neurotoxins (BoNTs) bind to polysialogangliosides, including GT1b, GD1b and GQ1b and synaptotagmin polypeptides on the neuronal plasma membrane (Verderio et al., 2006). In the body, this dual binding may have the effect of targeting BoNTs to specific regions of the neuromuscular junction for endocytosis. Different serotypes are known to bind to different receptors: Bont/A to SV2, Bont/B and G to Syt1 and Syt2 with different affinities. Edited: Gopinathrao, G, 2006-06-15 22:12:29 Reviewed: Ichtchenko, K, 2007-08-03 18:17:25 |
|
| definition source |
Pubmed12417130 Pubmed14504267 Reactome, http://www.reactome.org Pubmed9783260 Pubmed10932256 Pubmed17016457 |
|
| has input | ||
| has output | ||
| label |
Binding of BoNT toxins to gut epithelial membrane |
|
| prefixIRI |
HINO:0026836 |
|
| prefLabel |
Binding of BoNT toxins to gut epithelial membrane |
|
| seeAlso |
Reactome Database ID Release 43181359 ReactomeREACT_11084 |
|
| subClassOf |