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Transcytosis and internalization of BoNT |
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Authored: Krupa, S, Gopinathrao, G, 2006-06-15 10:36:11 Once BoNT molecules are bound to the host cell surface via their HC domains, they undergo transcytosis which include sorting and endocytosis into an acidic vesicular compartment within the cytosol. As a result of endocytosis, the toxin becomes resistant to neutralization by antisera. Endocytosis is temperature and energy-dependent. In the body, endocytosed BoNT molecules remain associated with the neuromuscular junction which they finally reach by transcytosis. Edited: Gopinathrao, G, 2006-06-15 22:12:29 Reviewed: Ichtchenko, K, 2007-08-03 18:17:25 |
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http://purl.obolibrary.org/obo/HINO_0026740 |
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Authored: Krupa, S, Gopinathrao, G, 2006-06-15 10:36:11 Once BoNT molecules are bound to the host cell surface via their HC domains, they undergo transcytosis which include sorting and endocytosis into an acidic vesicular compartment within the cytosol. As a result of endocytosis, the toxin becomes resistant to neutralization by antisera. Endocytosis is temperature and energy-dependent. In the body, endocytosed BoNT molecules remain associated with the neuromuscular junction which they finally reach by transcytosis. Edited: Gopinathrao, G, 2006-06-15 22:12:29 Reviewed: Ichtchenko, K, 2007-08-03 18:17:25 |
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| definition source |
Pubmed12417130 Reactome, http://www.reactome.org Pubmed10212474 Pubmed4273827 Pubmed92475 |
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Transcytosis and internalization of BoNT |
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HINO:0026740 |
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Transcytosis and internalization of BoNT |
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ReactomeREACT_11086 Reactome Database ID Release 43181536 |
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