loading...| Preferred Name |
Pore or channel formation in endosomal membrane |
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| Definitions |
Authored: Krupa, S, Gopinathrao, G, 2006-06-15 10:36:11 Acidic pH triggers a conformation change in the Heavy chain N-terminal domain leading to its insertion into the lipid bilayer and formation of a trans-membrane channel large enough to accommodate the unfolded Light chain. It has been observed that in the closely related Diptheria toxin, a 10-aa motif is critical for pore formation. Ratts et al. identified this motif in some of the virulent BoNTs (Ratts et al., 2005). Edited: Gopinathrao, G, 2006-06-15 22:12:29 Reviewed: Ichtchenko, K, 2007-08-03 18:17:25 |
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http://purl.obolibrary.org/obo/HINO_0026738 |
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| comment |
Authored: Krupa, S, Gopinathrao, G, 2006-06-15 10:36:11 Acidic pH triggers a conformation change in the Heavy chain N-terminal domain leading to its insertion into the lipid bilayer and formation of a trans-membrane channel large enough to accommodate the unfolded Light chain. It has been observed that in the closely related Diptheria toxin, a 10-aa motif is critical for pore formation. Ratts et al. identified this motif in some of the virulent BoNTs (Ratts et al., 2005). Edited: Gopinathrao, G, 2006-06-15 22:12:29 Reviewed: Ichtchenko, K, 2007-08-03 18:17:25 |
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| definition source |
Pubmed16230620 Pubmed8206166 Reactome, http://www.reactome.org Pubmed2446925 |
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| label |
Pore or channel formation in endosomal membrane |
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| prefixIRI |
HINO:0026738 |
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Pore or channel formation in endosomal membrane |
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| seeAlso |
Reactome Database ID Release 43181361 ReactomeREACT_11217 |
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