Link to this page
Human Interaction Network Ontology
| Preferred Name | activated human TAK1 phosphorylates MKK3/MKK6 | |
| Synonyms |
|
|
| Definitions |
has a Stoichiometric coefficient of 2 Edited: Shamovsky, V, 2011-08-12 Reviewed: Gillespie, ME, 2010-02-27 Human MKK3 and MKK6 are two closely related dual-specificity protein kinases. Both are activated by cellular stress and inflammatory cytokines, and both phosphorylate and activate p38 MAP kinase at its activation site Thr-Gly-Tyr but do not phosphorylate or activate Erk1/2 or SAPK/JNK.<p> Activation of MKK3 and MKK6 occurs through phosphorylation of serine and threonine residues at the typical Ser-Xaa-Ala-Xaa-Thr motif in their activation loop. Residues involved into these protein kinases activation correspond to human sites Ser189 and Thr193 for MKK3 and Ser207 and Thr211 for MKK6 . Authored: Shamovsky, V, 2009-12-16 |
|
| ID |
http://purl.obolibrary.org/obo/HINO_0026736 |
|
| comment |
has a Stoichiometric coefficient of 2 Edited: Shamovsky, V, 2011-08-12 Reviewed: Gillespie, ME, 2010-02-27 Human MKK3 and MKK6 are two closely related dual-specificity protein kinases. Both are activated by cellular stress and inflammatory cytokines, and both phosphorylate and activate p38 MAP kinase at its activation site Thr-Gly-Tyr but do not phosphorylate or activate Erk1/2 or SAPK/JNK.<p> Activation of MKK3 and MKK6 occurs through phosphorylation of serine and threonine residues at the typical Ser-Xaa-Ala-Xaa-Thr motif in their activation loop. Residues involved into these protein kinases activation correspond to human sites Ser189 and Thr193 for MKK3 and Ser207 and Thr211 for MKK6 . Authored: Shamovsky, V, 2009-12-16
|
|
| definition source |
Pubmed8533096 Reactome, http://www.reactome.org Pubmed8622669 Pubmed15837794 Pubmed16186825
|
|
| has input | ||
| has output | ||
| label |
activated human TAK1 phosphorylates MKK3/MKK6
|
|
| prefixIRI |
HINO:0026736
|
|
| prefLabel |
activated human TAK1 phosphorylates MKK3/MKK6
|
|
| seeAlso |
Reactome Database ID Release 43450346 ReactomeREACT_21338 EC Number: 2.7.11
|
|
| subClassOf |
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |