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Human Interaction Network Ontology
| Preferred Name | Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 | |
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| Definitions |
p38 MAPK alpha does not have a nuclear export signal (NES) and cannot leave the nucleus by itself, but rather needs to be associated with MAP kinase-activated protein kinase 2 (MAPKAPK2 or MK2). The NES of MAPKAPK2 facilitates the transport of both kinases from the nucleus to the cytoplasm but only after MK2 has been phosphorylated by p38alpha.<p>p38 MAPK alpha phosphorylates MK2 at Thr222, Ser272, and Thr334. The phosphorylation of Thr334 but not the kinase activity of MK2 has been demonstrated to be critical for the nuclear export of the p38 alpha - MK2 complex. Phosphorylation of Thr334 is believed to induce a conformational change in the complex exposing NES prior to interaction with the leptomycin B-sensitive nuclear export receptor. Edited: Shamovsky, V, 2010-02-27 Reviewed: Gillespie, ME, 2010-02-27 Authored: Shamovsky, V, 2009-12-16 |
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http://purl.obolibrary.org/obo/HINO_0026417 |
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| comment |
p38 MAPK alpha does not have a nuclear export signal (NES) and cannot leave the nucleus by itself, but rather needs to be associated with MAP kinase-activated protein kinase 2 (MAPKAPK2 or MK2). The NES of MAPKAPK2 facilitates the transport of both kinases from the nucleus to the cytoplasm but only after MK2 has been phosphorylated by p38alpha.<p>p38 MAPK alpha phosphorylates MK2 at Thr222, Ser272, and Thr334. The phosphorylation of Thr334 but not the kinase activity of MK2 has been demonstrated to be critical for the nuclear export of the p38 alpha - MK2 complex. Phosphorylation of Thr334 is believed to induce a conformational change in the complex exposing NES prior to interaction with the leptomycin B-sensitive nuclear export receptor. Edited: Shamovsky, V, 2010-02-27 Reviewed: Gillespie, ME, 2010-02-27 Authored: Shamovsky, V, 2009-12-16
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| definition source |
Pubmed12171911 Reactome, http://www.reactome.org Pubmed9768359
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Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3
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| prefixIRI |
HINO:0026417
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Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3
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ReactomeREACT_21358 Reactome Database ID Release 43450257
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