has a Stoichiometric coefficient of 2 Authored: Luo, F, 2005-11-10 11:23:18 Edited: Shamovsky, V, 2009-12-16 the Raf–MEK–ERK pathway induces phosphorylation of ATF2 Thr71, whereas subsequent ATF2 Thr69 phosphorylation requires the Ral–RalGDS–Src–p38 pathway. Cooperation between ERK and p38 was found to be essential for ATF2 activation by these mitogens; the activity of p38 and JNK/SAPK in growth factor-stimulated fibroblasts is insufficient to phosphorylate ATF2 Thr71 or Thr69 + 71 significantly by themselves, while ERK cannot dual phosphorylate ATF2 Thr69 + 71 efficiently. Reviewed: Gay, NJ, 2006-04-24 16:48:17 At the beginning of this reaction, 1 molecule of 'ATP', and 1 molecule of 'ATF-2' are present. At the end of this reaction, 1 molecule of 'ADP', and 1 molecule of 'ATF-2-P' are present.<br><br> This reaction is mediated by the 'protein kinase activity' of 'MAPK1-P'.<br>

http://purl.obolibrary.org/obo/HINO_0026378

has a Stoichiometric coefficient of 2

Authored: Luo, F, 2005-11-10 11:23:18

Edited: Shamovsky, V, 2009-12-16

the Raf–MEK–ERK pathway induces phosphorylation of ATF2 Thr71, whereas subsequent ATF2 Thr69 phosphorylation requires the Ral–RalGDS–Src–p38 pathway. Cooperation between ERK and p38 was found to be essential for ATF2 activation by these mitogens; the activity of p38 and JNK/SAPK in growth factor-stimulated fibroblasts is insufficient to phosphorylate ATF2 Thr71 or Thr69 + 71 significantly by themselves, while ERK cannot dual phosphorylate ATF2 Thr69 + 71 efficiently.

Reviewed: Gay, NJ, 2006-04-24 16:48:17

At the beginning of this reaction, 1 molecule of 'ATP', and 1 molecule of 'ATF-2' are present. At the end of this reaction, 1 molecule of 'ADP', and 1 molecule of 'ATF-2-P' are present.

This reaction is mediated by the 'protein kinase activity' of 'MAPK1-P'.

Pubmed10878576

Reactome, http://www.reactome.org

Pubmed19647037

Pubmed12110590

http://purl.obolibrary.org/obo/CHEBI_15422

http://purl.obolibrary.org/obo/UniProt_P15336

http://purl.obolibrary.org/obo/CHEBI_16761

http://purl.obolibrary.org/obo/UniProt_P15336

Phosphorylated MAPKs phosphorylate ATF-2

HINO:0026378

Phosphorylated MAPKs phosphorylate ATF-2

EC Number: 2.7.11

Reactome Database ID Release 43168053

ReactomeREACT_6719

http://purl.obolibrary.org/obo/INO_0000040