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Human Interaction Network Ontology
Last uploaded:
June 27, 2014
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| Id | http://purl.obolibrary.org/obo/HINO_0026237
http://purl.obolibrary.org/obo/HINO_0026237
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|---|---|
| Preferred Name | Translocation of ZAP-70 to Immunological synapse |
| Definitions |
The dual phosphorylated ITAMs recruit Syk kinase ZAP-70 via their tandem SH2 domains (step 4). ZAP-70 subsequently undergoes phosphorylation on multiple tyrosine residues for further activation. ZAP-70 includes both positive and negative regulatory sites. Tyrosine 493 is a conserved regulatory site found within the activation loop of the kinase domain. This site has shown to be a positive regulatory site required for ZAP-70 kinase activity and is phosphorylated by Lck (step 5). This phosphorylation contributes to the active conformation of the catalytic domain. Later ZAP-70 undergoes trans-autophosphorylation at Y315 and Y319 (step 6). These sites appear to be positive regulatory sites. ZAP-70 achieves its full activation after the trans-autophosphorylation. Activated ZAP-70 along with Lck phosphorylates the multiple tyrosine residues in the adaptor protein LAT (step 7).
Reviewed: Trowsdale, J, 2008-02-26 12:02:59
Authored: Rudd, C.E., de Bono, B, Garapati, P V, 2008-01-24 15:53:10
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| label |
Translocation of ZAP-70 to Immunological synapse
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|---|---|
| comment |
The dual phosphorylated ITAMs recruit Syk kinase ZAP-70 via their tandem SH2 domains (step 4). ZAP-70 subsequently undergoes phosphorylation on multiple tyrosine residues for further activation. ZAP-70 includes both positive and negative regulatory sites. Tyrosine 493 is a conserved regulatory site found within the activation loop of the kinase domain. This site has shown to be a positive regulatory site required for ZAP-70 kinase activity and is phosphorylated by Lck (step 5). This phosphorylation contributes to the active conformation of the catalytic domain. Later ZAP-70 undergoes trans-autophosphorylation at Y315 and Y319 (step 6). These sites appear to be positive regulatory sites. ZAP-70 achieves its full activation after the trans-autophosphorylation. Activated ZAP-70 along with Lck phosphorylates the multiple tyrosine residues in the adaptor protein LAT (step 7).
Reviewed: Trowsdale, J, 2008-02-26 12:02:59
Authored: Rudd, C.E., de Bono, B, Garapati, P V, 2008-01-24 15:53:10
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| prefLabel |
Translocation of ZAP-70 to Immunological synapse
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| located_in | |
| definition source |
Pubmed10375551
Reactome, http://www.reactome.org
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| prefixIRI |
HINO:0026237
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| seeAlso |
ReactomeREACT_12596
Reactome Database ID Release 43202430
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| subClassOf | |
| type | |
| has_part |
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