loading...| Preferred Name | CD28 co-stimulation | |
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| Definitions |
In naive T cells, CD28 costimulation enhances cell cycle entry, potently stimulates expression of both the mitogenic lymphokine interleukin-2 (IL-2) and its receptor, and stimulates the activation of an antiapoptotic program. CD28 engages with one or both members of the B7 receptor family, B7.1 and B7.2. Upon ligand binding the tyrosines and proline-rich motifs present in the cytoplasmic tail of CD28 are phosphorylated by Lck or Fyn. Upon phosphorylation CD28 recruits and induces phosphorylation and activation of a more restricted set of intracellular signaling components that, together with those mobilized by the TCR, contribute to convert membrane-based biochemical and biophysical changes into gene activation events. Proteins like PI3K, Vav-1, Tec and Itk kinases, AKT, and the Dok-1 adaptor have been identified as elements of the CD28 signaling pathway by biochemical or genetic approaches or both. Authored: Garapati, P V, 2008-12-16 11:12:19 Reviewed: Bluestone, JA, Esensten, J, 2009-06-01 18:47:33 Edited: Garapati, P V, 2008-12-16 11:12:19 |
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| ID |
http://purl.obolibrary.org/obo/HINO_0026229 |
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| comment |
In naive T cells, CD28 costimulation enhances cell cycle entry, potently stimulates expression of both the mitogenic lymphokine interleukin-2 (IL-2) and its receptor, and stimulates the activation of an antiapoptotic program. CD28 engages with one or both members of the B7 receptor family, B7.1 and B7.2. Upon ligand binding the tyrosines and proline-rich motifs present in the cytoplasmic tail of CD28 are phosphorylated by Lck or Fyn. Upon phosphorylation CD28 recruits and induces phosphorylation and activation of a more restricted set of intracellular signaling components that, together with those mobilized by the TCR, contribute to convert membrane-based biochemical and biophysical changes into gene activation events. Proteins like PI3K, Vav-1, Tec and Itk kinases, AKT, and the Dok-1 adaptor have been identified as elements of the CD28 signaling pathway by biochemical or genetic approaches or both. Authored: Garapati, P V, 2008-12-16 11:12:19 Reviewed: Bluestone, JA, Esensten, J, 2009-06-01 18:47:33 Edited: Garapati, P V, 2008-12-16 11:12:19 |
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| definition source |
Pubmed12165654 Reactome, http://www.reactome.org Pubmed8649453 Pubmed8609386 |
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| label |
CD28 co-stimulation |
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| located_in | ||
| prefixIRI |
HINO:0026229 |
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| prefLabel |
CD28 co-stimulation |
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| seeAlso |
GENE ONTOLOGYGO:0031295 ReactomeREACT_19183 Reactome Database ID Release 43389356 |
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| subClassOf | ||
| has_part |
http://purl.obolibrary.org/obo/HINO_0017788 http://purl.obolibrary.org/obo/HINO_0017786 http://purl.obolibrary.org/obo/HINO_0017787 http://purl.obolibrary.org/obo/HINO_0017785 |