Link to this page
Human Interaction Network Ontology
| Preferred Name | Activation of Matrix Metalloproteinases | |
| Synonyms |
|
|
| Definitions |
Reviewed: Butler, GS, 2012-02-28 Reviewed: Overall, CM, 2012-02-28 The matrix metalloproteinases (MMPs), previously known as matrixins, are classically known to be involved in the turnover of extracellular matrix (ECM) components. However, recent high throughput proteomics analyses have revealed that ~80% of MMP substrates are non-ECM proteins including cytokines, growth factor binding protiens, and receptors. It is now clear that MMPs regulate ECM turnover not only by cleaving ECM components, but also by the regulation of cell signalling, and that some MMPs are beneficial and may be drug anti-targets. Thus, MMPs have important roles in many processes including embryo development, morphogenesis, tissue homeostasis and remodeling. They are implicated in several diseases such as arthritis, periodontitis, glomerulonephritis, atherosclerosis, tissue ulceration, and cancer cell invasion and metastasis. All MMPs are synthesized as preproenzymes. Alternate splice forms are known, leading to nuclear localization of select MMPs. Most are secreted from the cell, or in the case of membrane type (MT) MMPs become plasma membrane associated, as inactive proenzymes. Their subsequent activation is a key regulatory step, with requirements specific to MMP subtype. Edited: Jupe, S, 2012-02-21 Authored: Jupe, S, 2011-09-09 |
|
| ID |
http://purl.obolibrary.org/obo/HINO_0026131 |
|
| comment |
Reviewed: Butler, GS, 2012-02-28 Reviewed: Overall, CM, 2012-02-28 The matrix metalloproteinases (MMPs), previously known as matrixins, are classically known to be involved in the turnover of extracellular matrix (ECM) components. However, recent high throughput proteomics analyses have revealed that ~80% of MMP substrates are non-ECM proteins including cytokines, growth factor binding protiens, and receptors. It is now clear that MMPs regulate ECM turnover not only by cleaving ECM components, but also by the regulation of cell signalling, and that some MMPs are beneficial and may be drug anti-targets. Thus, MMPs have important roles in many processes including embryo development, morphogenesis, tissue homeostasis and remodeling. They are implicated in several diseases such as arthritis, periodontitis, glomerulonephritis, atherosclerosis, tissue ulceration, and cancer cell invasion and metastasis. All MMPs are synthesized as preproenzymes. Alternate splice forms are known, leading to nuclear localization of select MMPs. Most are secreted from the cell, or in the case of membrane type (MT) MMPs become plasma membrane associated, as inactive proenzymes. Their subsequent activation is a key regulatory step, with requirements specific to MMP subtype. Edited: Jupe, S, 2012-02-21 Authored: Jupe, S, 2011-09-09
|
|
| definition source |
ISBN0 19 850268 0 Pubmed19616423 Pubmed17562450 Pubmed19817485 Pubmed19800373 Reactome, http://www.reactome.org
|
|
| label |
Activation of Matrix Metalloproteinases
|
|
| located_in | ||
| prefixIRI |
HINO:0026131
|
|
| prefLabel |
Activation of Matrix Metalloproteinases
|
|
| seeAlso |
Reactome Database ID Release 431592389 ReactomeREACT_118682
|
|
| subClassOf | ||
| has_part |
http://purl.obolibrary.org/obo/HINO_0021666 http://purl.obolibrary.org/obo/HINO_0021668 http://purl.obolibrary.org/obo/HINO_0021664 http://purl.obolibrary.org/obo/HINO_0021667 http://purl.obolibrary.org/obo/HINO_0021665 http://purl.obolibrary.org/obo/HINO_0021663 http://purl.obolibrary.org/obo/HINO_0021612 http://purl.obolibrary.org/obo/HINO_0021640 http://purl.obolibrary.org/obo/HINO_0021623 http://purl.obolibrary.org/obo/HINO_0021629 http://purl.obolibrary.org/obo/HINO_0021627 http://purl.obolibrary.org/obo/HINO_0021626 http://purl.obolibrary.org/obo/HINO_0021621 http://purl.obolibrary.org/obo/HINO_0021622 http://purl.obolibrary.org/obo/HINO_0021625 http://purl.obolibrary.org/obo/HINO_0021624 http://purl.obolibrary.org/obo/HINO_0021628 http://purl.obolibrary.org/obo/HINO_0021635 http://purl.obolibrary.org/obo/HINO_0021631 http://purl.obolibrary.org/obo/HINO_0021637 http://purl.obolibrary.org/obo/HINO_0021633 http://purl.obolibrary.org/obo/HINO_0021632 http://purl.obolibrary.org/obo/HINO_0021638 http://purl.obolibrary.org/obo/HINO_0021630 http://purl.obolibrary.org/obo/HINO_0021634 |
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |