Human Interaction Network Ontology

Last uploaded: June 27, 2014
Preferred Name

phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP

Synonyms
Definitions

Authored: D'Eustachio, P, 2005-04-04 21:01:34 The first step of GPI synthesis is the transfer of N-acetylglucosamine from cytosolic UDP-N-acetylglucosamine to phosphatidyl inositol (PI) in the endoplasmic reticulum membrane. The reaction is catalyzed by a multimeric enzyme, also localized to the endoplasmic reticulum membrane, six components of which have been identified to date by mutagenesis studies in cultured cells and by co-recipitation studies in vitro (Watanabe et al. 1996, 1998, 2000). Edited: D'Eustachio, P, 0000-00-00 00:00:00

ID

http://purl.obolibrary.org/obo/HINO_0025933

comment

Authored: D'Eustachio, P, 2005-04-04 21:01:34

The first step of GPI synthesis is the transfer of N-acetylglucosamine from cytosolic UDP-N-acetylglucosamine to phosphatidyl inositol (PI) in the endoplasmic reticulum membrane. The reaction is catalyzed by a multimeric enzyme, also localized to the endoplasmic reticulum membrane, six components of which have been identified to date by mutagenesis studies in cultured cells and by co-recipitation studies in vitro (Watanabe et al. 1996, 1998, 2000).

Edited: D'Eustachio, P, 0000-00-00 00:00:00

definition source

Pubmed9463366

Pubmed10944123

Reactome, http://www.reactome.org

Pubmed8900170

has input

http://purl.obolibrary.org/obo/CHEBI_16264

http://purl.obolibrary.org/obo/CHEBI_16749

has output

http://purl.obolibrary.org/obo/CHEBI_15935

http://purl.obolibrary.org/obo/CHEBI_17659

label

phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP

prefixIRI

HINO:0025933

prefLabel

phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP

seeAlso

ReactomeREACT_1240

Reactome Database ID Release 43162730

subClassOf

http://purl.obolibrary.org/obo/INO_0000040

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