loading...| Preferred Name |
EIF5A + spermidine <=> EIF5A(Dhp) + 1,3-diaminopropane |
|
| Synonyms |
|
|
| Definitions |
Authored: Johansson, HE, 2007-11-28 23:26:30 Reviewed: Jassal, B, 2008-01-28 15:51:00 Edited: D'Eustachio, P, 2007-11-28 23:33:46 Cytosolic deoxyhypusine synthase catalyzes the reaction of EIF5A protein, spermidine, and NAD+ to convert lysine-50 of EIF5A to deoxyhypusine, generating 1,3-diaminopropane and NADH + H+ in the process (Park 2006). Although the reaction is reversible, the reverse reaction is probably minimized under physiological conditions by the rapid, irreversible conversion of EIF5A(Dhp) to EIF5A(Hyp). |
|
| ID |
http://purl.obolibrary.org/obo/HINO_0025916 |
|
| comment |
Authored: Johansson, HE, 2007-11-28 23:26:30 Reviewed: Jassal, B, 2008-01-28 15:51:00 Edited: D'Eustachio, P, 2007-11-28 23:33:46 Cytosolic deoxyhypusine synthase catalyzes the reaction of EIF5A protein, spermidine, and NAD+ to convert lysine-50 of EIF5A to deoxyhypusine, generating 1,3-diaminopropane and NADH + H+ in the process (Park 2006). Although the reaction is reversible, the reverse reaction is probably minimized under physiological conditions by the rapid, irreversible conversion of EIF5A(Dhp) to EIF5A(Hyp). |
|
| definition source |
Reactome, http://www.reactome.org Pubmed7673224 Pubmed16452303 Pubmed14622290 Pubmed9188485 |
|
| has input |
http://purl.obolibrary.org/obo/CHEBI_16610 |
|
| has output |
http://purl.obolibrary.org/obo/CHEBI_15725 http://purl.obolibrary.org/obo/CHEBI_16908 |
|
| label |
EIF5A + spermidine <=> EIF5A(Dhp) + 1,3-diaminopropane |
|
| prefixIRI |
HINO:0025916 |
|
| prefLabel |
EIF5A + spermidine <=> EIF5A(Dhp) + 1,3-diaminopropane |
|
| seeAlso |
EC Number: 2.5.1.46 ReactomeREACT_12551 Reactome Database ID Release 43204647 |
|
| subClassOf |