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Human Interaction Network Ontology
| Preferred Name | Association of CCT/TriC with other substrates during biosynthesis (unknown chaperone) | |
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| Definitions |
Reviewed: Cowan, NJ, 2009-01-21 16:47:24 A combination of proteomic and bioinformatics analyses of TRiC substrates has revealed that they have complex topologies that are slow folding and aggregation prone (Yam et al., 2008). These substrates are also enriched in proteins that belong to oligomeric assemblies suggesting that TRiC plays a role in promoting complex assembly (Yam et al., 2008). Two possible mechanisms describing the role of TriC have been suggested (Yam et al., 2008). The processes of TRiC-mediated folding and assembly could be directly coupled, or TRiC could fold monomeric subunits and hold them in an assembly-competent state until they associate with the appropriate partner subunits. The complete list of TriC subsrates is not yet known. Many of its substrates that are targeted during biosynthesis are conserved between mammals and yeast (Yam et al. 2008). Edited: Matthews, L, 2009-02-21 05:37:28 Authored: Matthews, L, 2008-12-01 04:46:41 |
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http://purl.obolibrary.org/obo/HINO_0025884 |
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| comment |
Reviewed: Cowan, NJ, 2009-01-21 16:47:24 A combination of proteomic and bioinformatics analyses of TRiC substrates has revealed that they have complex topologies that are slow folding and aggregation prone (Yam et al., 2008). These substrates are also enriched in proteins that belong to oligomeric assemblies suggesting that TRiC plays a role in promoting complex assembly (Yam et al., 2008). Two possible mechanisms describing the role of TriC have been suggested (Yam et al., 2008). The processes of TRiC-mediated folding and assembly could be directly coupled, or TRiC could fold monomeric subunits and hold them in an assembly-competent state until they associate with the appropriate partner subunits. The complete list of TriC subsrates is not yet known. Many of its substrates that are targeted during biosynthesis are conserved between mammals and yeast (Yam et al. 2008). Edited: Matthews, L, 2009-02-21 05:37:28 Authored: Matthews, L, 2008-12-01 04:46:41
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| definition source |
Reactome, http://www.reactome.org Pubmed19011634
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| label |
Association of CCT/TriC with other substrates during biosynthesis (unknown chaperone)
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| prefixIRI |
HINO:0025884
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| prefLabel |
Association of CCT/TriC with other substrates during biosynthesis (unknown chaperone)
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| seeAlso |
Reactome Database ID Release 43390470 ReactomeREACT_16984
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