loading...| Preferred Name | Removal of repair proteins and ligation of the processed ends of the DNA double-strand break | |
| Synonyms |
|
|
| Definitions |
has a Stoichiometric coefficient of 2 Presumably the proteins must be released from the DNA prior to end joining but precisely when this step occurs is not known. Mg-ATP and the protein kinase activity of DNA-PKcs are required for repair of DNA double strand breaks (Kurimasa et al, 1999; Kienker et al, 2000; Baumann and West, 1998). In vitro, DNA-PK undergoes autophosphorylation which correlates with loss of protein kinase activity and disruption of the DNA-PKcs-Ku-DNA complex (Chan and Lees-Miller, 1996; Douglas et al, 2001; 2002; Merkle et al, 2002). Moreover, autophosphorylation of DNA-PKcs is required for NHEJ in vivo (Chan et al, 2002; Ding et al, 2003), suggesting that autophosphorylation may serve as a mechanism to remove DNA-PKcs from DNA prior to end joining. Authored: Matthews, L, 2003-09-07 08:47:00 has a Stoichiometric coefficient of 4 |
|
| ID |
http://purl.obolibrary.org/obo/HINO_0025719 |
|
| comment |
has a Stoichiometric coefficient of 2 Presumably the proteins must be released from the DNA prior to end joining but precisely when this step occurs is not known. Mg-ATP and the protein kinase activity of DNA-PKcs are required for repair of DNA double strand breaks (Kurimasa et al, 1999; Kienker et al, 2000; Baumann and West, 1998). In vitro, DNA-PK undergoes autophosphorylation which correlates with loss of protein kinase activity and disruption of the DNA-PKcs-Ku-DNA complex (Chan and Lees-Miller, 1996; Douglas et al, 2001; 2002; Merkle et al, 2002). Moreover, autophosphorylation of DNA-PKcs is required for NHEJ in vivo (Chan et al, 2002; Ding et al, 2003), suggesting that autophosphorylation may serve as a mechanism to remove DNA-PKcs from DNA prior to end joining. Authored: Matthews, L, 2003-09-07 08:47:00 has a Stoichiometric coefficient of 4 |
|
| definition source |
Pubmed12379113 Pubmed11376007 Reactome, http://www.reactome.org Pubmed10908332 Pubmed10207111 Pubmed12231622 Pubmed12897153 Pubmed12186630 Pubmed8621537 Pubmed9826654 |
|
| has input | ||
| has output |
http://purl.obolibrary.org/obo/UniProt_P78527 http://purl.obolibrary.org/obo/UniProt_P12956 http://purl.obolibrary.org/obo/HINO_0008688 http://purl.obolibrary.org/obo/UniProt_P49917 |
|
| label |
Removal of repair proteins and ligation of the processed ends of the DNA double-strand break |
|
| prefixIRI |
HINO:0025719 |
|
| prefLabel |
Removal of repair proteins and ligation of the processed ends of the DNA double-strand break |
|
| seeAlso |
Reactome Database ID Release 4375928 ReactomeREACT_12 |
|
| subClassOf |