Human Interaction Network Ontology

Last uploaded: June 27, 2014
Preferred Name

Phosphorylation of NBS1 by ATM
Synonyms
Definitions

NSB1 is a component of the MRE11/RAD50/NBS1 complex which acts early in HRR during resection of the double-strand break. In addition, NBS1 is required for activation of the S-phase checkpoint in response to ionizing radiation (IR), ATM-dependent activation of CHK2 and cell survival after exposure to IR. Authored: Matthews, L, 2003-11-18 00:00:00

ID

http://purl.obolibrary.org/obo/HINO_0025075

comment

NSB1 is a component of the MRE11/RAD50/NBS1 complex which acts early in HRR during resection of the double-strand break. In addition, NBS1 is required for activation of the S-phase checkpoint in response to ionizing radiation (IR), ATM-dependent activation of CHK2 and cell survival after exposure to IR.

Authored: Matthews, L, 2003-11-18 00:00:00

definition source

Pubmed12861053

Reactome, http://www.reactome.org

has input

http://purl.obolibrary.org/obo/UniProt_O60934

http://purl.obolibrary.org/obo/CHEBI_15422

has output

http://purl.obolibrary.org/obo/UniProt_O60934

http://purl.obolibrary.org/obo/CHEBI_16761

label

Phosphorylation of NBS1 by ATM

prefixIRI

HINO:0025075

prefLabel

Phosphorylation of NBS1 by ATM

seeAlso

ReactomeREACT_2009

Reactome Database ID Release 4375241

subClassOf

http://purl.obolibrary.org/obo/INO_0000040

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