loading...| Preferred Name | Phosphorylation of histone H2AX at Serine-139 by ATM at the site of DSB | |
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| Definitions |
H2AX phosphorylation (producing the gamma-H2AX protein form) occurs within 1-3 minutes of DNA damage (Rogakou et al,1998) and is promoted by MDC1/NFBD1 (Stewart et al., 2003). gamma H2AX is one of the first proteins to appear at the site of damage, localizing to a region of about 2 Mbp surrounding the site of the double-strand break (Rogakou et al,1998). gamma-H2AX appears to play an essential role in recruiting other repair proteins including Rad50, Rad51 and BRCA1(Paull et al., 2000) (Stewart et al., 2003). Authored: Matthews, L, 2003-08-11 05:43:00 |
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http://purl.obolibrary.org/obo/HINO_0025073 |
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H2AX phosphorylation (producing the gamma-H2AX protein form) occurs within 1-3 minutes of DNA damage (Rogakou et al,1998) and is promoted by MDC1/NFBD1 (Stewart et al., 2003). gamma H2AX is one of the first proteins to appear at the site of damage, localizing to a region of about 2 Mbp surrounding the site of the double-strand break (Rogakou et al,1998). gamma-H2AX appears to play an essential role in recruiting other repair proteins including Rad50, Rad51 and BRCA1(Paull et al., 2000) (Stewart et al., 2003). Authored: Matthews, L, 2003-08-11 05:43:00 |
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| definition source |
Reactome, http://www.reactome.org Pubmed9488723 Pubmed12607005 Pubmed10959836 |
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Phosphorylation of histone H2AX at Serine-139 by ATM at the site of DSB |
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HINO:0025073 |
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Phosphorylation of histone H2AX at Serine-139 by ATM at the site of DSB |
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ReactomeREACT_1517 Reactome Database ID Release 4375242 |
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