loading...| Preferred Name | Resection of double-strand break ends | |
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| Definitions |
In order for repair of the double-strand break to occur, the 5' ends of the break must first be resected to produce single-strands that invade homologous duplex DNA. Although the enzymatic activities responsible for end-processing in humans are not known with certainty, the MRE11-RAD50-NBS1 (MRN) complex has been implicated in this process (Thompson and Schild, 2001). The MRN complex may function as a bridge between double-strand break ends through interactions between the coiled-coil domains of RAD50 (Hoptner et al., 2002). Authored: Matthews, L, 2003-08-11 05:43:00 |
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http://purl.obolibrary.org/obo/HINO_0025045 |
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In order for repair of the double-strand break to occur, the 5' ends of the break must first be resected to produce single-strands that invade homologous duplex DNA. Although the enzymatic activities responsible for end-processing in humans are not known with certainty, the MRE11-RAD50-NBS1 (MRN) complex has been implicated in this process (Thompson and Schild, 2001). The MRN complex may function as a bridge between double-strand break ends through interactions between the coiled-coil domains of RAD50 (Hoptner et al., 2002). Authored: Matthews, L, 2003-08-11 05:43:00 |
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| definition source |
Pubmed11376695 Reactome, http://www.reactome.org Pubmed12152085 Pubmed9705271 Pubmed11139606 |
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Resection of double-strand break ends |
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HINO:0025045 |
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Resection of double-strand break ends |
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Reactome Database ID Release 4383897 GENE ONTOLOGYGO:0000729 ReactomeREACT_172 |
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