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Human Interaction Network Ontology
Last uploaded:
June 27, 2014
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| Preferred Name | PRLR:JAK2 dimerizes | |
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| Definitions |
has a Stoichiometric coefficient of 2 Reviewed: Goffin, V, 2011-11-08 Authored: Jupe, S, 2011-06-13 The prolactin receptor (PRLR) peptide is a single transmembrane domain protein that functions as a dimer. Recent reports suggest that like many other cytokine receptors, the prolactin receptor (PRLR) pre-assembles at the plasma membrane in the absence of ligand (Gadd & Clevenger 2006, Tallet et al. 2011), suggesting that ligand-induced activation involves conformational changes in the preformed receptor dimer (Broutin et al. 2010). Edited: Jupe, S, 2011-10-17 |
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| ID |
http://purl.obolibrary.org/obo/HINO_0024439 |
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| comment |
has a Stoichiometric coefficient of 2 Reviewed: Goffin, V, 2011-11-08 Authored: Jupe, S, 2011-06-13 The prolactin receptor (PRLR) peptide is a single transmembrane domain protein that functions as a dimer. Recent reports suggest that like many other cytokine receptors, the prolactin receptor (PRLR) pre-assembles at the plasma membrane in the absence of ligand (Gadd & Clevenger 2006, Tallet et al. 2011), suggesting that ligand-induced activation involves conformational changes in the preformed receptor dimer (Broutin et al. 2010). Edited: Jupe, S, 2011-10-17
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| definition source |
Reactome, http://www.reactome.org Pubmed16840534 Pubmed20053995
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| label |
PRLR:JAK2 dimerizes
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| prefixIRI |
HINO:0024439
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| prefLabel |
PRLR:JAK2 dimerizes
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| seeAlso |
Reactome Database ID Release 431364044 ReactomeREACT_115881
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