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Human Interaction Network Ontology
Last uploaded:
June 27, 2014
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| Id | http://purl.obolibrary.org/obo/HINO_0024420
http://purl.obolibrary.org/obo/HINO_0024420
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|---|---|
| Preferred Name | PRLR is phosphorylated at Ser-349 |
| Definitions |
has a Stoichiometric coefficient of 2
Reviewed: Goffin, V, 2011-11-08
Authored: Jupe, S, 2011-06-13
The PRL responsiveness of target cells is negatively regulated by receptor internalization, ubiquitination and degradation, which limit the duration and intensity of receptor signaling (Djiane et al. 1981, 1982, Lu et al. 2002). The PRLR is phosphorylated on Ser-349 by an unidentified kinase (Li et al. 2006) enabling subsequent recruitment of the SCF beta-TrCP ubiquitin ligase complex (Li et al. 2004).
Edited: Jupe, S, 2011-10-17
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| label |
PRLR is phosphorylated at Ser-349
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| comment |
has a Stoichiometric coefficient of 2
Reviewed: Goffin, V, 2011-11-08
Authored: Jupe, S, 2011-06-13
The PRL responsiveness of target cells is negatively regulated by receptor internalization, ubiquitination and degradation, which limit the duration and intensity of receptor signaling (Djiane et al. 1981, 1982, Lu et al. 2002). The PRLR is phosphorylated on Ser-349 by an unidentified kinase (Li et al. 2006) enabling subsequent recruitment of the SCF beta-TrCP ubiquitin ligase complex (Li et al. 2004).
Edited: Jupe, S, 2011-10-17
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| prefLabel |
PRLR is phosphorylated at Ser-349
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| definition source |
Pubmed6276249
Pubmed12403840
Reactome, http://www.reactome.org
Pubmed15082796
Pubmed6275396
Pubmed16278670
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| prefixIRI |
HINO:0024420
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| seeAlso |
ReactomeREACT_115844
Reactome Database ID Release 431370505
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| has input | |
| has output |
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