loading...| Preferred Name | Prolactin receptor is internalized | |
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| Definitions |
PRLR is regulated by ubiquitination of the activated receptor, leading to lysosomal degradation (Djiane et al. 1981, 1982, Lu et al. 2002). Recruitment of the SCFbeta-TrCP ubiquitin ligase complex enables receptor ubiquitination and internalization (Li et al. 2004). This limits the duration and intensity of receptor signaling. Deregulation of this negative control lead to pathological conditions including cancer (Swaminathan et al. 2008). Reviewed: Goffin, V, 2011-11-08 Authored: Jupe, S, 2011-06-13 Edited: Jupe, S, 2011-10-17 |
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http://purl.obolibrary.org/obo/HINO_0024418 |
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| comment |
PRLR is regulated by ubiquitination of the activated receptor, leading to lysosomal degradation (Djiane et al. 1981, 1982, Lu et al. 2002). Recruitment of the SCFbeta-TrCP ubiquitin ligase complex enables receptor ubiquitination and internalization (Li et al. 2004). This limits the duration and intensity of receptor signaling. Deregulation of this negative control lead to pathological conditions including cancer (Swaminathan et al. 2008). Reviewed: Goffin, V, 2011-11-08 Authored: Jupe, S, 2011-06-13 Edited: Jupe, S, 2011-10-17 |
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| definition source |
Pubmed18204982 Pubmed6276249 Pubmed12403840 Reactome, http://www.reactome.org Pubmed15082796 Pubmed6275396 |
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| label |
Prolactin receptor is internalized |
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| prefixIRI |
HINO:0024418 |
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| prefLabel |
Prolactin receptor is internalized |
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| seeAlso |
Reactome Database ID Release 431170539 ReactomeREACT_115907 |
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