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Human Interaction Network Ontology
Last uploaded:
June 27, 2014
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| Preferred Name | PRLR binds SHP2 (PTPN11) | |
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| Definitions |
Reviewed: Goffin, V, 2011-11-08 Authored: Jupe, S, 2011-06-13 Tyrosine-phosphorylated PRLR can bind the protein-tyrosine Phosphatase SHP2 (PTPN11) via its C-terminal SH2 Domain. This binding does not occur when the most C-terminal PRLR tyrosine residue (residue 611 in the human canonical Uniprot sequence, equivalent to 587 in the mature protein with signal peptide removed) is mutated to alanine (Ali & Ali 2000). Edited: Jupe, S, 2011-10-17 |
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| ID |
http://purl.obolibrary.org/obo/HINO_0024412 |
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| comment |
Reviewed: Goffin, V, 2011-11-08 Authored: Jupe, S, 2011-06-13 Tyrosine-phosphorylated PRLR can bind the protein-tyrosine Phosphatase SHP2 (PTPN11) via its C-terminal SH2 Domain. This binding does not occur when the most C-terminal PRLR tyrosine residue (residue 611 in the human canonical Uniprot sequence, equivalent to 587 in the mature protein with signal peptide removed) is mutated to alanine (Ali & Ali 2000). Edited: Jupe, S, 2011-10-17
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| definition source |
Pubmed10991949 Reactome, http://www.reactome.org
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| label |
PRLR binds SHP2 (PTPN11)
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| prefixIRI |
HINO:0024412
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| prefLabel |
PRLR binds SHP2 (PTPN11)
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| seeAlso |
Reactome Database ID Release 431369114 ReactomeREACT_115782
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