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Human Interaction Network Ontology
Last uploaded:
June 27, 2014
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| Preferred Name | PRLR-bound STAT5 is phosphorylated | |
| Synonyms |
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| Definitions |
has a Stoichiometric coefficient of 2 Reviewed: Goffin, V, 2011-11-08 Authored: Jupe, S, 2011-06-13 Co-immunoprecipitation of rat Stat5 and Prlrs mutated to have a single intracellular tyrosine suggests that phosphorylation of these tyrosines is required for Stat5 binding and leads to Stat5 tyrosine phosphorylation (Pezet et al. 1997). STAT1 and STAT3 have both been reported to be activated by PRLR (DaSilva et al. 1996), but the region(s) of PRLR required for activation of these Stats remains poorly documented. Edited: Jupe, S, 2011-10-17 |
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| ID |
http://purl.obolibrary.org/obo/HINO_0024410 |
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| comment |
has a Stoichiometric coefficient of 2 Reviewed: Goffin, V, 2011-11-08 Authored: Jupe, S, 2011-06-13 Co-immunoprecipitation of rat Stat5 and Prlrs mutated to have a single intracellular tyrosine suggests that phosphorylation of these tyrosines is required for Stat5 binding and leads to Stat5 tyrosine phosphorylation (Pezet et al. 1997). STAT1 and STAT3 have both been reported to be activated by PRLR (DaSilva et al. 1996), but the region(s) of PRLR required for activation of these Stats remains poorly documented. Edited: Jupe, S, 2011-10-17
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| definition source |
Reactome, http://www.reactome.org Pubmed9312112 Pubmed8737372
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| label |
PRLR-bound STAT5 is phosphorylated
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| prefixIRI |
HINO:0024410
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| prefLabel |
PRLR-bound STAT5 is phosphorylated
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| seeAlso |
EC Number: 2.7.10 ReactomeREACT_115938 Reactome Database ID Release 431671691
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