loading...| Preferred Name | Cross-presentation of particulate exogenous antigens (phagosomes) | |
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| Definitions |
Authored: Garapati, P V, 2011-03-28 Dendritic cells (DCs) take up and process exogenous particulate or cell-associated antigens such as microbes or tumor cells for MHC-I cross-presentation. Particulate antigens have been reported to be more efficiently cross-presented than soluble antigens by DCs (Khor et al. 2008). Particulate antigens are internalized by phagosomes. There are two established models that explain the mechanism by which exogenous particulate antigens are presented through MHC I; the cytosolic pathway where internalized antigens are somehow translocated from phagosomes into cytosol for proteasomal degradation and the vacuolar pathway (Lin et al. 2008, Amigorena et al. 2010). Edited: Garapati, P V, 2011-03-28 Reviewed: Desjardins, M, English, L, 2011-05-13 |
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http://purl.obolibrary.org/obo/HINO_0022407 |
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| comment |
Authored: Garapati, P V, 2011-03-28 Dendritic cells (DCs) take up and process exogenous particulate or cell-associated antigens such as microbes or tumor cells for MHC-I cross-presentation. Particulate antigens have been reported to be more efficiently cross-presented than soluble antigens by DCs (Khor et al. 2008). Particulate antigens are internalized by phagosomes. There are two established models that explain the mechanism by which exogenous particulate antigens are presented through MHC I; the cytosolic pathway where internalized antigens are somehow translocated from phagosomes into cytosol for proteasomal degradation and the vacuolar pathway (Lin et al. 2008, Amigorena et al. 2010). Edited: Garapati, P V, 2011-03-28 Reviewed: Desjardins, M, English, L, 2011-05-13 |
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| definition source |
Pubmed20028659 Reactome, http://www.reactome.org Pubmed18572095 Pubmed20171863 Pubmed18268517 |
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Cross-presentation of particulate exogenous antigens (phagosomes) |
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HINO:0022407 |
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Cross-presentation of particulate exogenous antigens (phagosomes) |
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GENE ONTOLOGYGO:0002479 ReactomeREACT_111174 Reactome Database ID Release 431236973 |
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http://purl.obolibrary.org/obo/HINO_0018190 http://purl.obolibrary.org/obo/HINO_0018196 http://purl.obolibrary.org/obo/HINO_0018186 http://purl.obolibrary.org/obo/HINO_0018187 |