loading...| Preferred Name | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | |
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| Definitions |
Reviewed: Elliott, T, 2011-02-10 Unlike other glycoproteins, correct folding of MHC class I molecules is not sufficient to trigger their exit from the ER, they exit only after peptide loading. Described here is the process of antigen presentation which consists of the folding, assembly, and peptide loading of MHC class I molecules. The newly synthesized MHC class I Heavy Chain (HC) is initially folded with the help of several chaperones (calnexin, BiP, ERp57) and then binds with Beta-2-microglobulin (B2M). This MHC:B2M heterodimer enters the peptide loading complex (PLC), a multiprotein complex that includes calreticulin, endoplasmic reticulum resident protein 57 (ERp57), transporter associated with antigen processing (TAP) and tapasin. Peptides generated from Ub-proteolysis are transported into the ER through TAP. These peptides are further trimmed by ER-associated aminopeptidase (ERAP) and loaded on to MHC class I molecules. Stable MHC class I trimers with high-affinity peptide are transported from the ER to the cell surface by the Golgi apparatus. Authored: Garapati, P V, 2010-10-29 Edited: Garapati, P V, 2010-10-29 |
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| ID |
http://purl.obolibrary.org/obo/HINO_0022403 |
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| comment |
Reviewed: Elliott, T, 2011-02-10 Unlike other glycoproteins, correct folding of MHC class I molecules is not sufficient to trigger their exit from the ER, they exit only after peptide loading. Described here is the process of antigen presentation which consists of the folding, assembly, and peptide loading of MHC class I molecules. The newly synthesized MHC class I Heavy Chain (HC) is initially folded with the help of several chaperones (calnexin, BiP, ERp57) and then binds with Beta-2-microglobulin (B2M). This MHC:B2M heterodimer enters the peptide loading complex (PLC), a multiprotein complex that includes calreticulin, endoplasmic reticulum resident protein 57 (ERp57), transporter associated with antigen processing (TAP) and tapasin. Peptides generated from Ub-proteolysis are transported into the ER through TAP. These peptides are further trimmed by ER-associated aminopeptidase (ERAP) and loaded on to MHC class I molecules. Stable MHC class I trimers with high-affinity peptide are transported from the ER to the cell surface by the Golgi apparatus. Authored: Garapati, P V, 2010-10-29 Edited: Garapati, P V, 2010-10-29 |
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| definition source |
Pubmed12495737 Pubmed18641646 Pubmed18926908 Reactome, http://www.reactome.org Pubmed15224092 Pubmed19178136 |
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| label |
Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
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| located_in | ||
| prefixIRI |
HINO:0022403 |
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| prefLabel |
Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
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| seeAlso |
Reactome Database ID Release 43983170 ReactomeREACT_75795 |
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| subClassOf | ||
| has_part |
http://purl.obolibrary.org/obo/HINO_0018264 http://purl.obolibrary.org/obo/HINO_0018169 http://purl.obolibrary.org/obo/HINO_0018166 http://purl.obolibrary.org/obo/HINO_0018168 http://purl.obolibrary.org/obo/HINO_0018167 http://purl.obolibrary.org/obo/HINO_0018165 http://purl.obolibrary.org/obo/HINO_0018164 http://purl.obolibrary.org/obo/HINO_0018230 http://purl.obolibrary.org/obo/HINO_0018232 http://purl.obolibrary.org/obo/HINO_0018231 http://purl.obolibrary.org/obo/HINO_0018171 http://purl.obolibrary.org/obo/HINO_0018170 |