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Human Interaction Network Ontology
Last uploaded:
June 27, 2014
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| Id | http://purl.obolibrary.org/obo/HINO_0022394
http://purl.obolibrary.org/obo/HINO_0022394
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|---|---|
| Preferred Name | Endosomal/Vacuolar pathway |
| Definitions |
Some antigens are cross-presented through a vacuolar mechanism that involves generation of antigenic peptides and their loading on to MHC-I molecules within the endosomal compartment in a proteasome and TAP-independent manner. Antigens within the endosome are processed by cathepsin S and other proteases into antigenic peptides. Loading of these peptides onto MHC-I molecules occurs directly within early and late endosomal compartments. Why certain antigens are cross-presented exclusively by the cytosolic pathway while others use the vacuolar pathway is unknown. It may be because some epitopes cannot be generated by endosomal proteolysis, or are completely destroyed. Alternatively, the physical form of the antigen may influence its accessibility to the endosomal or vacuolar pathways (Shen et al. 2004).
Authored: Garapati, P V, 2011-03-28
Edited: Garapati, P V, 2011-03-28
Reviewed: Desjardins, M, English, L, 2011-05-13
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| label |
Endosomal/Vacuolar pathway
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|---|---|
| comment |
Some antigens are cross-presented through a vacuolar mechanism that involves generation of antigenic peptides and their loading on to MHC-I molecules within the endosomal compartment in a proteasome and TAP-independent manner. Antigens within the endosome are processed by cathepsin S and other proteases into antigenic peptides. Loading of these peptides onto MHC-I molecules occurs directly within early and late endosomal compartments. Why certain antigens are cross-presented exclusively by the cytosolic pathway while others use the vacuolar pathway is unknown. It may be because some epitopes cannot be generated by endosomal proteolysis, or are completely destroyed. Alternatively, the physical form of the antigen may influence its accessibility to the endosomal or vacuolar pathways (Shen et al. 2004).
Authored: Garapati, P V, 2011-03-28
Edited: Garapati, P V, 2011-03-28
Reviewed: Desjardins, M, English, L, 2011-05-13
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| prefLabel |
Endosomal/Vacuolar pathway
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| located_in | |
| definition source |
Reactome, http://www.reactome.org
Pubmed15308097
Pubmed18376401
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| prefixIRI |
HINO:0022394
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| seeAlso |
GENE ONTOLOGYGO:0002480
Reactome Database ID Release 431236977
ReactomeREACT_111168
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| subClassOf | |
| type | |
| has_part |
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