Human Interaction Network Ontology

Last uploaded: June 27, 2014
Preferred Name

PDI is a chaperone for collagen peptides
Synonyms
Definitions

Authored: Jupe, S, 2010-07-20 Edited: Jupe, S, 2012-05-14 Reviewed: Canty-Laird, EG, 2012-05-24 As the collagen peptide chain is translocated across the membrane of the endoplasmic reticulum, intrachain disulfide bonds are formed within the N- and C-propeptides. This allows the triple helical domain to form a nucleation point at its C-terminal end and ensures correct alignment of the chains (Engel & Prockop 1991). Protein disulfide isomerase (P4HB) catalyzes the formation of both intra- (Bulleid & Freedman 1988) and inter-chain disulfide bonds (Koivu & Myllylä 1987). In addition, PDI acts as a molecular chaperone, interacting with monomeric collagen propeptide chains to prevent premature assembly or aggregation (Wilson et al. 1998).

ID

http://purl.obolibrary.org/obo/HINO_0022390

comment

Authored: Jupe, S, 2010-07-20

Edited: Jupe, S, 2012-05-14

Reviewed: Canty-Laird, EG, 2012-05-24

As the collagen peptide chain is translocated across the membrane of the endoplasmic reticulum, intrachain disulfide bonds are formed within the N- and C-propeptides. This allows the triple helical domain to form a nucleation point at its C-terminal end and ensures correct alignment of the chains (Engel & Prockop 1991). Protein disulfide isomerase (P4HB) catalyzes the formation of both intra- (Bulleid & Freedman 1988) and inter-chain disulfide bonds (Koivu & Myllylä 1987). In addition, PDI acts as a molecular chaperone, interacting with monomeric collagen propeptide chains to prevent premature assembly or aggregation (Wilson et al. 1998).

definition source

Pubmed1867713

Reactome, http://www.reactome.org

Pubmed9560306

Pubmed9545296

Pubmed3571251

Pubmed3173483

has input

http://purl.obolibrary.org/obo/UniProt_P07237

http://purl.obolibrary.org/obo/HINO_0001638

has output

http://purl.obolibrary.org/obo/HINO_0019669

label

PDI is a chaperone for collagen peptides

prefixIRI

HINO:0022390

prefLabel

PDI is a chaperone for collagen peptides

seeAlso

ReactomeREACT_120881

Reactome Database ID Release 432002460

subClassOf

http://purl.obolibrary.org/obo/INO_0000040

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