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Human Interaction Network Ontology
Last uploaded:
June 27, 2014
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| Id | http://purl.obolibrary.org/obo/HINO_0022383
http://purl.obolibrary.org/obo/HINO_0022383
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|---|---|
| Preferred Name | PD-1 signaling |
| Definitions |
Authored: Garapati, P V, 2008-12-16 11:12:19
Reviewed: Bluestone, JA, Esensten, J, 2009-06-01 18:47:33
Edited: Garapati, P V, 2008-12-16 11:12:19
The Programmed cell death protein 1 (PD-1) is one of the negative regulators of TCR signaling. PD-1 may exert its effects on cell differentiation and survival directly by inhibiting early activation events that are positively regulated by CD28 or indirectly through IL-2. PD-1 ligation inhibits the induction of the cell survival factor Bcl-xL and the expression of transcription factors associated with effector cell function, including GATA-3, Tbet, and Eomes. PD-1 exerts its inhibitory effects by bringing phosphatases SHP-1 and SHP-2 into the immune synapse, leading to dephosphorylation of CD3-zeta chain, PI3K and AKT.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| label | PD-1 signaling
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|---|---|
| comment | Authored: Garapati, P V, 2008-12-16 11:12:19
Reviewed: Bluestone, JA, Esensten, J, 2009-06-01 18:47:33
Edited: Garapati, P V, 2008-12-16 11:12:19
The Programmed cell death protein 1 (PD-1) is one of the negative regulators of TCR signaling. PD-1 may exert its effects on cell differentiation and survival directly by inhibiting early activation events that are positively regulated by CD28 or indirectly through IL-2. PD-1 ligation inhibits the induction of the cell survival factor Bcl-xL and the expression of transcription factors associated with effector cell function, including GATA-3, Tbet, and Eomes. PD-1 exerts its inhibitory effects by bringing phosphatases SHP-1 and SHP-2 into the immune synapse, leading to dephosphorylation of CD3-zeta chain, PI3K and AKT.
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| prefLabel | PD-1 signaling
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| located_in | |
| definition source |
Pubmed18173375
Pubmed18759926
Reactome, http://www.reactome.org
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| prefixIRI | HINO:0022383
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| seeAlso |
Reactome Database ID Release 43389948
ReactomeREACT_19324
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| subClassOf | |
| type | |
| has_part |
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