loading...| Preferred Name | Activation of RAS in B Cells | |
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Edited: May, B, 2011-01-03 RasGRP1 and RasGRP3 bind diacylglycerol at the plasma membrane (Lorenzo et al. 2001) and are phosphorylated by protein kinase C (Teixeira et al. 2003, Zheng et al. 2005). Phosphorylated RasGRP1 (Roose et al. 2007) and RasGRP3 (Ohba et al. 2000, Yamashita et al. 2000, Rebhun et al. 2000, Lorenzo et al. 2001) then catalyze the exchange of GDP for GTP bound by RAS, thereby activating RAS. Authored: May, B, 2011-01-03 Reviewed: Wienands, J, 2012-02-11 |
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http://purl.obolibrary.org/obo/HINO_0022373 |
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Edited: May, B, 2011-01-03 RasGRP1 and RasGRP3 bind diacylglycerol at the plasma membrane (Lorenzo et al. 2001) and are phosphorylated by protein kinase C (Teixeira et al. 2003, Zheng et al. 2005). Phosphorylated RasGRP1 (Roose et al. 2007) and RasGRP3 (Ohba et al. 2000, Yamashita et al. 2000, Rebhun et al. 2000, Lorenzo et al. 2001) then catalyze the exchange of GDP for GTP bound by RAS, thereby activating RAS. Authored: May, B, 2011-01-03 Reviewed: Wienands, J, 2012-02-11 |
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| definition source |
Pubmed10777492 Pubmed10934204 Pubmed17283063 Pubmed10835426 Reactome, http://www.reactome.org Pubmed11221888 Pubmed12730099 Pubmed15657177 |
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Activation of RAS in B Cells |
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HINO:0022373 |
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Activation of RAS in B Cells |
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ReactomeREACT_118778 Reactome Database ID Release 431169092 |
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