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Human Interaction Network Ontology
| Preferred Name | Dimerization of procollagen type VI | |
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| Definitions |
has a Stoichiometric coefficient of 2 Collagen type VI forms dimers and tetramers before secretion (Furthmayr et al. 1983, von der Mark et al. 1984, Engel et al. 1985, Colombatti et al. 1987). The monomers associate in antiparallel with a 30nm axial shift, intertwining 4 or 5 times (Furthmayr et al. 1983). These associate laterally to form tetramers (Furthmayr et al. 1983, von der Mark et al. 1984)The tetramers associate to form microfibrils in a non-covalent manner, presumed to be mediated through A domain interactions (Baldock et al. 2003). Collagen type VI chains are extensively post translationally modifed by the hydroxylation of proline and lysine residues (Myllyharju & Kivirikko 2004) and subsequent glycosylation of hydroxylysine, thought to be essential for tetramer formation and secretion (Sipila et al. 2007). Authored: Jupe, S, 2010-07-20 Edited: Jupe, S, 2012-05-14 Reviewed: Canty-Laird, EG, 2012-05-24 |
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| ID |
http://purl.obolibrary.org/obo/HINO_0022370 |
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| comment |
has a Stoichiometric coefficient of 2 Collagen type VI forms dimers and tetramers before secretion (Furthmayr et al. 1983, von der Mark et al. 1984, Engel et al. 1985, Colombatti et al. 1987). The monomers associate in antiparallel with a 30nm axial shift, intertwining 4 or 5 times (Furthmayr et al. 1983). These associate laterally to form tetramers (Furthmayr et al. 1983, von der Mark et al. 1984)The tetramers associate to form microfibrils in a non-covalent manner, presumed to be mediated through A domain interactions (Baldock et al. 2003). Collagen type VI chains are extensively post translationally modifed by the hydroxylation of proline and lysine residues (Myllyharju & Kivirikko 2004) and subsequent glycosylation of hydroxylysine, thought to be essential for tetramer formation and secretion (Sipila et al. 2007). Authored: Jupe, S, 2010-07-20 Edited: Jupe, S, 2012-05-14 Reviewed: Canty-Laird, EG, 2012-05-24
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| definition source |
Pubmed6432530 Pubmed12473679 Pubmed14698617 Pubmed17873278 Reactome, http://www.reactome.org Pubmed3938630 Pubmed12823969 Pubmed3117786 Pubmed6307276
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| label |
Dimerization of procollagen type VI
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| prefixIRI |
HINO:0022370
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| prefLabel |
Dimerization of procollagen type VI
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| seeAlso |
Reactome Database ID Release 431614460 ReactomeREACT_121253
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