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Human Interaction Network Ontology
| Preferred Name | Association of procollagen chains | |
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| Definitions |
Authored: Jupe, S, 2010-07-20 Edited: Jupe, S, 2012-05-14 The C-propeptides are essential for the association of three alpha chains into a trimeric non-helical procollagen. Alignment determines the composition of the trimer, brings the individual chains into the correct register and initiates formation of the triple helix at the C-terminus, which then proceeds to the N-terminus in a zipper-like fashion (Engel & Prockop 1991). Most early refolding studies were performed with collagen type III which contains a disulfide linkage at the C-terminus of its triple helix (Bächinger et al. 1978, Bruckner et al. 1978) that acts as a permanent linker even after removal of the non-collagenous domains. <br><br>Mutations within the C-propeptides further suggest that they are crucial for the correct interaction of the three polypeptide chains and for subsequent correct folding (refs. in Boudko et al. 2011). Reviewed: Canty-Laird, EG, 2012-05-24 |
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http://purl.obolibrary.org/obo/HINO_0022368 |
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| comment |
Authored: Jupe, S, 2010-07-20 Edited: Jupe, S, 2012-05-14 The C-propeptides are essential for the association of three alpha chains into a trimeric non-helical procollagen. Alignment determines the composition of the trimer, brings the individual chains into the correct register and initiates formation of the triple helix at the C-terminus, which then proceeds to the N-terminus in a zipper-like fashion (Engel & Prockop 1991). Most early refolding studies were performed with collagen type III which contains a disulfide linkage at the C-terminus of its triple helix (Bächinger et al. 1978, Bruckner et al. 1978) that acts as a permanent linker even after removal of the non-collagenous domains. <br><br>Mutations within the C-propeptides further suggest that they are crucial for the correct interaction of the three polypeptide chains and for subsequent correct folding (refs. in Boudko et al. 2011). Reviewed: Canty-Laird, EG, 2012-05-24
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| definition source |
Pubmed710450 Pubmed1867713 Reactome, http://www.reactome.org Pubmed22001560 Pubmed171650 Pubmed710449
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| label |
Association of procollagen chains
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| prefixIRI |
HINO:0022368
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| prefLabel |
Association of procollagen chains
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| seeAlso |
ReactomeREACT_121254 Reactome Database ID Release 432002401
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