loading...| Preferred Name | TRIF-mediated TLR3/TLR4 signaling | |
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| Definitions |
Reviewed: Fitzgerald, Katherine A, 2012-11-13 TRIF was shown to induce IRF3/7 and NF-?B activation and apoptosis through distinct intracellular signaling pathways [Han KJ et al 2004; Kaiser WJ and Offermann MK et al 2005]. TRIF consists of an N-terminal region (1-234), a TIR domain (235-500), and a C-terminal region (501-680).<p> The N-terminal region of TRIF harbors TRAF (TNF receptor associated factor) family proteins and forms complexes containing IRF-3 and/or NFkB -activating kinases. The C-terminal region of TRIF can recruit receptor-interacting protein-1 (RIP-1), and this event is followed by the activation of IKK complex. Edited: Shamovsky, V, 2010-11-15 Reviewed: Gillespie, ME, 2010-11-30 Authored: Shamovsky, V, 2010-06-01 |
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http://purl.obolibrary.org/obo/HINO_0022344 |
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Reviewed: Fitzgerald, Katherine A, 2012-11-13 TRIF was shown to induce IRF3/7 and NF-?B activation and apoptosis through distinct intracellular signaling pathways [Han KJ et al 2004; Kaiser WJ and Offermann MK et al 2005]. TRIF consists of an N-terminal region (1-234), a TIR domain (235-500), and a C-terminal region (501-680). The N-terminal region of TRIF harbors TRAF (TNF receptor associated factor) family proteins and forms complexes containing IRF-3 and/or NFkB -activating kinases. The C-terminal region of TRIF can recruit receptor-interacting protein-1 (RIP-1), and this event is followed by the activation of IKK complex. Edited: Shamovsky, V, 2010-11-15 Reviewed: Gillespie, ME, 2010-11-30 Authored: Shamovsky, V, 2010-06-01 |
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| definition source |
Reactome, http://www.reactome.org Pubmed15814722 Pubmed14739303 Pubmed12855817 |
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| label |
TRIF-mediated TLR3/TLR4 signaling |
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| prefixIRI |
HINO:0022344 |
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| prefLabel |
TRIF-mediated TLR3/TLR4 signaling |
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| seeAlso |
ReactomeREACT_25281 Reactome Database ID Release 43937061 GENE ONTOLOGYGO:0035666 |
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http://purl.obolibrary.org/obo/HINO_0015703 http://purl.obolibrary.org/obo/HINO_0015704 http://purl.obolibrary.org/obo/HINO_0021958 http://purl.obolibrary.org/obo/HINO_0021961 |