loading...| Preferred Name | Toll Like Receptor TLR1:TLR2 Cascade | |
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| Definitions |
Reviewed: D'Eustachio, P, 2006-07-03 21:35:13 Authored: D'Eustachio, P, Gay, NJ, Gale M, Jr, Zwaginga, JJ, 2006-04-19 04:09:58 Edited: Shamovsky, V, 2012-11-06 TLR1 is expressed by monocytes. TLR1 and TLR2 cotranslationally form heterodimeric complexes on the cell surface and in the cytosol. The TLR2:TLR1 complex recognizes Neisserial PorB and Mycobacterial triacylated lipoproteins and peptides, amongst others, triggering up-regulation of nuclear factor-kappaB production and apoptotic cascades. Such cooperation between TLR1 and TLR2 on the cell surface of normal human peripheral blood mononuclear cells, for instance, leads to the activation of pro-inflammatory cytokine secretion (Sandor et al. 2003). |
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| ID |
http://purl.obolibrary.org/obo/HINO_0022316 |
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| comment |
Reviewed: D'Eustachio, P, 2006-07-03 21:35:13 Authored: D'Eustachio, P, Gay, NJ, Gale M, Jr, Zwaginga, JJ, 2006-04-19 04:09:58 Edited: Shamovsky, V, 2012-11-06 TLR1 is expressed by monocytes. TLR1 and TLR2 cotranslationally form heterodimeric complexes on the cell surface and in the cytosol. The TLR2:TLR1 complex recognizes Neisserial PorB and Mycobacterial triacylated lipoproteins and peptides, amongst others, triggering up-regulation of nuclear factor-kappaB production and apoptotic cascades. Such cooperation between TLR1 and TLR2 on the cell surface of normal human peripheral blood mononuclear cells, for instance, leads to the activation of pro-inflammatory cytokine secretion (Sandor et al. 2003). |
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| definition source |
Reactome, http://www.reactome.org Pubmed12975352 |
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| label |
Toll Like Receptor TLR1:TLR2 Cascade |
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| prefixIRI |
HINO:0022316 |
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| prefLabel |
Toll Like Receptor TLR1:TLR2 Cascade |
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| seeAlso |
Reactome Database ID Release 43168179 ReactomeREACT_8005 GENE ONTOLOGYGO:0034130 |
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| has_part |
http://purl.obolibrary.org/obo/HINO_0009131 |