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Human Interaction Network Ontology
Last uploaded:
June 27, 2014
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| Id | http://purl.obolibrary.org/obo/HINO_0022311
http://purl.obolibrary.org/obo/HINO_0022311
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|---|---|
| Preferred Name | Activated TLR4 signalling |
| Definitions |
Authored: de Bono, B, 2005-08-16 10:54:15
Reviewed: Gay, NJ, 2006-04-24 16:48:17
Edited: Shamovsky, V, 2012-11-06
Reviewed: Gillespie, ME, 2010-11-30
TLR4 is unique among the TLR family in its ability to recruit four adapters to activate two distinct signaling pathways. One pathway is activated by the pair of the adapters Mal or TIRAP (Toll/interleukin-1-receptor (TIR)-domain-containing adapter protein) and MyD88, which leads to the NFkB activation and the induction of pro-inflammatory cytokines. The second pathway is activated by the adapters TRIF (TIR-domain-containing adapter protein inducing interferon-beta) and TRAM (TRIF-related adapter molecule). The combined use of TRIF and TRAM adapters is specific for TLR4 signaling pathway and leads to the induction of type I interferons and delayed activation of NFkB.<p>The previous model of TLR4 signaling pathway described the simultaneous activation of these two signaling pathways at the plasma membrane, however the later studies suggested that upon activation TLR4 first induces TIRAP-MyD88 signaling at the plasma membrane and is then endocytosed and activates TRAM-TRIF signaling from the early endosome [Kagan JC et al 2008; Tanimura N et al 2008; Zanoni I et al 2011].
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| label |
Activated TLR4 signalling
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|---|---|
| comment |
Authored: de Bono, B, 2005-08-16 10:54:15
Reviewed: Gay, NJ, 2006-04-24 16:48:17
Edited: Shamovsky, V, 2012-11-06
Reviewed: Gillespie, ME, 2010-11-30
TLR4 is unique among the TLR family in its ability to recruit four adapters to activate two distinct signaling pathways. One pathway is activated by the pair of the adapters Mal or TIRAP (Toll/interleukin-1-receptor (TIR)-domain-containing adapter protein) and MyD88, which leads to the NFkB activation and the induction of pro-inflammatory cytokines. The second pathway is activated by the adapters TRIF (TIR-domain-containing adapter protein inducing interferon-beta) and TRAM (TRIF-related adapter molecule). The combined use of TRIF and TRAM adapters is specific for TLR4 signaling pathway and leads to the induction of type I interferons and delayed activation of NFkB.<p>The previous model of TLR4 signaling pathway described the simultaneous activation of these two signaling pathways at the plasma membrane, however the later studies suggested that upon activation TLR4 first induces TIRAP-MyD88 signaling at the plasma membrane and is then endocytosed and activates TRAM-TRIF signaling from the early endosome [Kagan JC et al 2008; Tanimura N et al 2008; Zanoni I et al 2011].
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| prefLabel |
Activated TLR4 signalling
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| located_in | |
| definition source |
Pubmed15588429
Pubmed15845500
Reactome, http://www.reactome.org
Pubmed14556004
Pubmed15276183
Pubmed18297073
Pubmed18222170
Pubmed15596121
Pubmed22078883
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| prefixIRI |
HINO:0022311
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| seeAlso |
ReactomeREACT_6890
GENE ONTOLOGYGO:0034142
Reactome Database ID Release 43166054
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| subClassOf | |
| type | |
| has_part |
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