loading...| Preferred Name | TRAF6 mediated NF-kB activation | |
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| Definitions |
Reviewed: Kawai, T, Akira, S, 2010-10-30 The TRAF6/TAK1 signal activates a canonical IKK complex, resulting in the activation of NF-kB as well as MAPK cascades leading to the activation of AP-1. Although TRAF6/TAK1 has been implicated in Tool like receptor (TLR) mediated cytokine production, the involvement of these molecules in the regulation of type I IFN induction mediated by RIG-I/MDA5 pathway is largely unknown. According to the study done by Yoshida et al RIG-I/IPS-1 pathway requires TRAF6 and MAP3K, MEKK1 to activate NF-kB and MAP Kinases for optimal induction of type I IFNs. Edited: Garapati, P V, 2010-08-02 Authored: Garapati, P V, 2010-08-02 |
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| ID |
http://purl.obolibrary.org/obo/HINO_0022281 |
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| comment |
Reviewed: Kawai, T, Akira, S, 2010-10-30 The TRAF6/TAK1 signal activates a canonical IKK complex, resulting in the activation of NF-kB as well as MAPK cascades leading to the activation of AP-1. Although TRAF6/TAK1 has been implicated in Tool like receptor (TLR) mediated cytokine production, the involvement of these molecules in the regulation of type I IFN induction mediated by RIG-I/MDA5 pathway is largely unknown. According to the study done by Yoshida et al RIG-I/IPS-1 pathway requires TRAF6 and MAP3K, MEKK1 to activate NF-kB and MAP Kinases for optimal induction of type I IFNs. Edited: Garapati, P V, 2010-08-02 Authored: Garapati, P V, 2010-08-02 |
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| definition source |
Reactome, http://www.reactome.org Pubmed18984593 |
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| label |
TRAF6 mediated NF-kB activation |
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| prefixIRI |
HINO:0022281 |
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| prefLabel |
TRAF6 mediated NF-kB activation |
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| seeAlso |
Reactome Database ID Release 43933542 ReactomeREACT_24969 |
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http://purl.obolibrary.org/obo/HINO_0007922 http://purl.obolibrary.org/obo/HINO_0007921 |