loading...| Preferred Name | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | |
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| Definitions |
Reviewed: Kawai, T, Akira, S, 2010-10-30 Edited: Garapati, P V, 2010-08-02 Authored: Garapati, P V, 2010-08-02 Fas-associateddeathdomain (FADD) and receptor interacting protein 1 (RIP1) are death domain containing molecules that interact with the C-terminal portion of IPS-1 and induce NF-kB through interaction and activation of initiator caspases (caspase-8 and -10). Caspases are usually involved in apoptosis and inflammation but they also exhibit nonapoptotic functions. These nonapoptotic caspase functions involve prodomain-mediated activation of NF-kB. Processed caspases (caspase-8/10) encoding the DED (death effector domain)starongly activate NF-kB. The exact mechanism by which caspases mediate NF-kB activation is unclear but the prodomains of caspase-8/10 may act as scaffolding and allow the recruitment of IKK complex in proximity with other signaling molecules. |
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http://purl.obolibrary.org/obo/HINO_0022279 |
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| comment |
Reviewed: Kawai, T, Akira, S, 2010-10-30 Edited: Garapati, P V, 2010-08-02 Authored: Garapati, P V, 2010-08-02 Fas-associateddeathdomain (FADD) and receptor interacting protein 1 (RIP1) are death domain containing molecules that interact with the C-terminal portion of IPS-1 and induce NF-kB through interaction and activation of initiator caspases (caspase-8 and -10). Caspases are usually involved in apoptosis and inflammation but they also exhibit nonapoptotic functions. These nonapoptotic caspase functions involve prodomain-mediated activation of NF-kB. Processed caspases (caspase-8/10) encoding the DED (death effector domain)starongly activate NF-kB. The exact mechanism by which caspases mediate NF-kB activation is unclear but the prodomains of caspase-8/10 may act as scaffolding and allow the recruitment of IKK complex in proximity with other signaling molecules. |
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| definition source |
Pubmed12884866 Pubmed16127453 Reactome, http://www.reactome.org Pubmed16585540 Pubmed16618810 |
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| label |
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 |
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| prefixIRI |
HINO:0022279 |
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| prefLabel |
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 |
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| seeAlso |
ReactomeREACT_25039 Reactome Database ID Release 43933543 |
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http://purl.obolibrary.org/obo/HINO_0007942 http://purl.obolibrary.org/obo/HINO_0007941 http://purl.obolibrary.org/obo/HINO_0007944 |