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Human Interaction Network Ontology
| Preferred Name | TRAF3-dependent IRF activation pathway | |
| Synonyms |
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| Definitions |
Reviewed: Kawai, T, Akira, S, 2010-10-30 Edited: Garapati, P V, 2010-08-02 Authored: Garapati, P V, 2010-08-02 IPS-1/MAVS/Cardif/VISA with its TRAF-interaction motif (TIM) directly interacts with TRAF3 and recruits TRAF3 to the RIG-I/MDA5 signaling complex. TRAF3 acts as a scaffold for the assembly of a signaling complex composed of IKK epsilon/TBK1, leading to the activation of transcription factors IRF3/IRF7. |
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| ID |
http://purl.obolibrary.org/obo/HINO_0022278 |
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| comment |
Reviewed: Kawai, T, Akira, S, 2010-10-30 Edited: Garapati, P V, 2010-08-02 Authored: Garapati, P V, 2010-08-02 IPS-1/MAVS/Cardif/VISA with its TRAF-interaction motif (TIM) directly interacts with TRAF3 and recruits TRAF3 to the RIG-I/MDA5 signaling complex. TRAF3 acts as a scaffold for the assembly of a signaling complex composed of IKK epsilon/TBK1, leading to the activation of transcription factors IRF3/IRF7.
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| definition source |
Reactome, http://www.reactome.org Pubmed16306936 Pubmed17190786
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| label |
TRAF3-dependent IRF activation pathway
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| located_in | ||
| prefixIRI |
HINO:0022278
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| prefLabel |
TRAF3-dependent IRF activation pathway
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| seeAlso |
Reactome Database ID Release 43918233 ReactomeREACT_25026
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| subClassOf | ||
| has_part |
http://purl.obolibrary.org/obo/HINO_0007952 http://purl.obolibrary.org/obo/HINO_0007956 http://purl.obolibrary.org/obo/HINO_0007958 http://purl.obolibrary.org/obo/HINO_0007950 http://purl.obolibrary.org/obo/HINO_0007954 http://purl.obolibrary.org/obo/HINO_0007960 http://purl.obolibrary.org/obo/HINO_0007965 |
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