loading...| Preferred Name | Negative regulators of RIG-I/MDA5 signaling | |
| Synonyms |
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| Definitions |
Reviewed: Kawai, T, Akira, S, 2010-10-30 Edited: Garapati, P V, 2010-08-02 Authored: Garapati, P V, 2010-08-02 As with other cytokine systems, production of type I IFN is a transient process, and can be hazardous to the host if unregulated, resulting in chronic cellular toxicity or inflammatory and autoimmune diseases. RIG-I-mediated production of IFN can, in turn, increase the transcription of RIG-I itself, thus setting into motion an IFN amplification loop, which if left unchecked, could become deleterious to the host. This module mainly focuses on the endogenous negative regulation of the RIG-I-like receptor (RLR) family proteins RIG-I and MDA5. |
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| ID |
http://purl.obolibrary.org/obo/HINO_0022268 |
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| comment |
Reviewed: Kawai, T, Akira, S, 2010-10-30 Edited: Garapati, P V, 2010-08-02 Authored: Garapati, P V, 2010-08-02 As with other cytokine systems, production of type I IFN is a transient process, and can be hazardous to the host if unregulated, resulting in chronic cellular toxicity or inflammatory and autoimmune diseases. RIG-I-mediated production of IFN can, in turn, increase the transcription of RIG-I itself, thus setting into motion an IFN amplification loop, which if left unchecked, could become deleterious to the host. This module mainly focuses on the endogenous negative regulation of the RIG-I-like receptor (RLR) family proteins RIG-I and MDA5. |
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| definition source |
Pubmed18703349 Reactome, http://www.reactome.org Pubmed18549796 |
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| label |
Negative regulators of RIG-I/MDA5 signaling |
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| located_in | ||
| prefixIRI |
HINO:0022268 |
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| prefLabel |
Negative regulators of RIG-I/MDA5 signaling |
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| seeAlso |
ReactomeREACT_25271 Reactome Database ID Release 43936440 GENE ONTOLOGYGO:0032480 |
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| subClassOf | ||
| has_part |
http://purl.obolibrary.org/obo/HINO_0007908 http://purl.obolibrary.org/obo/HINO_0007906 http://purl.obolibrary.org/obo/HINO_0008070 http://purl.obolibrary.org/obo/HINO_0008085 http://purl.obolibrary.org/obo/HINO_0008083 http://purl.obolibrary.org/obo/HINO_0008087 http://purl.obolibrary.org/obo/HINO_0008088 http://purl.obolibrary.org/obo/HINO_0008082 http://purl.obolibrary.org/obo/HINO_0008084 http://purl.obolibrary.org/obo/HINO_0008086 http://purl.obolibrary.org/obo/HINO_0007923 |