Link to this page
Human Interaction Network Ontology
| Preferred Name | IRF3 mediated activation of type 1 IFN | |
| Synonyms |
|
|
| Definitions |
Interferon regulatory factors (IRF) IRF-3 and IRF-7 are the major modulators of IFN gene expression in response to pathogenic molecules. The relative contribution of IRF3 and IRF7 depends on the signaling pathway that is activated. Type I IFN production in cytosolic DNA-sensing pathway is mediated predominantly by IRF3 and partially by IRF7, since DNA-stimulated IFN-beta and IFN-alpha4 mRNA induction was strongly inhibited in IRF3-deficient mouse embryonic fibroblasts (MEFs), while remained normal (IFN-beta) or reduced (IFN-alpha4) in IRF7-deficient MEFs (Takaoke A et al 2007). IRF3 activation in response to B-DNA stimulation occurs via its co-recruitment with serine/threonine kinase TANK-binding kinase 1 (TBK1) or inducible IkB kinase (IKKi/IKKepsilon) to the C-terminal region of DAI. Reviewed: D'Eustachio, P, 2011-12-07 Reviewed: Upton, JW, Mocarski, ES, 2012--0-2- Edited: Shamovsky, V, 2012-02-23 Authored: Shamovsky, V, 2011-09-21 |
|
| ID |
http://purl.obolibrary.org/obo/HINO_0022263 |
|
| comment |
Interferon regulatory factors (IRF) IRF-3 and IRF-7 are the major modulators of IFN gene expression in response to pathogenic molecules. The relative contribution of IRF3 and IRF7 depends on the signaling pathway that is activated. Type I IFN production in cytosolic DNA-sensing pathway is mediated predominantly by IRF3 and partially by IRF7, since DNA-stimulated IFN-beta and IFN-alpha4 mRNA induction was strongly inhibited in IRF3-deficient mouse embryonic fibroblasts (MEFs), while remained normal (IFN-beta) or reduced (IFN-alpha4) in IRF7-deficient MEFs (Takaoke A et al 2007). IRF3 activation in response to B-DNA stimulation occurs via its co-recruitment with serine/threonine kinase TANK-binding kinase 1 (TBK1) or inducible IkB kinase (IKKi/IKKepsilon) to the C-terminal region of DAI. Reviewed: D'Eustachio, P, 2011-12-07 Reviewed: Upton, JW, Mocarski, ES, 2012--0-2- Edited: Shamovsky, V, 2012-02-23 Authored: Shamovsky, V, 2011-09-21
|
|
| definition source |
Pubmed18375758 Reactome, http://www.reactome.org Pubmed19846511 Pubmed16413926 Pubmed17618271
|
|
| label |
IRF3 mediated activation of type 1 IFN
|
|
| located_in | ||
| prefixIRI |
HINO:0022263
|
|
| prefLabel |
IRF3 mediated activation of type 1 IFN
|
|
| seeAlso |
ReactomeREACT_118811 Reactome Database ID Release 431606341
|
|
| subClassOf | ||
| has_part |
http://purl.obolibrary.org/obo/HINO_0008033 http://purl.obolibrary.org/obo/HINO_0007997 http://purl.obolibrary.org/obo/HINO_0007992 |
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |